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A Mini-Review on EGFR-Tyrosine Kinase Inhibitors and their Resistance Mechanisms.
Curr Pharm Des
March 2025
Pharmacy Department, Tishk International University, Erbil, Iraq.
Background: An essential component of cell development, proliferation, and survival is the transmembrane receptor known as the epidermal growth factor receptor (EGFR). Dysregulated EGFR signalling is an appealing pathway that has been linked to the genesis and progression of several cancer types. EGFR tyrosine kinase inhibitors (TKIs) are targeted drugs that show promise in the fight against cancer.
View Article and Find Full Text PDFFactors influencing physicians' antimicrobial prescribing decisions: A systematic review of qualitative studies.
Br J Clin Pharmacol
March 2025
School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.
Inappropriate and overuse of antimicrobials is increasing antimicrobial resistance. Understanding physicians' antimicrobial decision-making is essential for developing interventions to optimize prescribing. The aim of this review was to identify the factors that influence physicians' antimicrobial prescribing decisions.
View Article and Find Full Text PDFMicrobiological Profiles and Resistance Patterns in Pediatrics With Cancer: An 8-Year Study at a Comprehensive Cancer Center in Jordan.
Cancer Rep (Hoboken)
March 2025
Department of Pediatrics, King Hussein Cancer Center, Amman, Jordan.
Introduction: Infections impact morbidity and mortality in pediatric cancer patients, yet limited studies have assessed the microbiological profiles and susceptibility patterns of pathogenic bacteria in this population. This study aimed to investigate bacterial profiles and temporal resistance changes in pediatrics with cancer.
Methods: We identified positive cultures between January 2015 and December 2022 for pediatric patients diagnosed with cancer at age < 18 years.
The Journey of Resistant Hypertension: From the Fifth Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure to American Heart Association/American College of Cardiology Guidelines.
Circulation
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Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor (A.F.T.).
"After torture, everything changed": the unpacking of trauma from torture with interpretative phenomenological analysis and Merleau-Ponty's theory of the lived body.
BMC Psychol
March 2025
Institute of Nursing and Health Promotion, Oslo Metropolitan University, Oslo, Norway.
Background: Trauma from torture is expressed primarily through bodily sensations and emotions, reflecting its deep imprint on the body's memory. Merleau-Ponty's existential phenomenology, which emphasizes the lived body, provides a valuable framework for discussing the intricate interplay between physical and psychological experiences. Through this approach, we gain a deeper understanding of the profound impact of torture on survivors, which in turn informs holistic recovery strategies.
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