Phytochemical investigation of the flowers of led to the isolation of eight compounds. They consist of one undescribed polyphenolic isoprenylated acetophenone benzofuran, acronyculatin S (), and seven known compounds: demethylacrovestone (), acrovestone (), acroflavone A (), 3,5,4'-trihydroxy-3',8-dimethoxy-7-(3-methylbut-2-enyloxy)flavone (), xanthotoxin (), isopimpinellin () and -methylflindersine (). The structures of the isolated compounds were elucidated by thorough analysis of spectroscopic (IR, NMR and ECD) and spectrometric (MS) data. Compounds and were tested against seven bacterial strains. They displayed significant activities against methicillin-resistant and with MIC values in the range of 2-8 µg/mL.
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http://dx.doi.org/10.1080/14786419.2025.2477221 | DOI Listing |
Nat Prod Res
March 2025
Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Phytochemical investigation of the flowers of led to the isolation of eight compounds. They consist of one undescribed polyphenolic isoprenylated acetophenone benzofuran, acronyculatin S (), and seven known compounds: demethylacrovestone (), acrovestone (), acroflavone A (), 3,5,4'-trihydroxy-3',8-dimethoxy-7-(3-methylbut-2-enyloxy)flavone (), xanthotoxin (), isopimpinellin () and -methylflindersine (). The structures of the isolated compounds were elucidated by thorough analysis of spectroscopic (IR, NMR and ECD) and spectrometric (MS) data.
View Article and Find Full Text PDFACS Synth Biol
September 2024
School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, 2 Xuelin Road, Qixia District, Nanjing 210046, People's Republic of China.
Flavonoids, a significant group of natural polyphenolic compounds, possess a broad spectrum of pharmacological effects. Recent advances in the systematic metabolic engineering of yeast cell factories (YCFs) provide new opportunities for enhanced flavonoid production. Herein, we outline the latest research progress on typical flavonoid products in YCFs.
View Article and Find Full Text PDFNat Prod Res
February 2025
Metabolomics Research Group, Departamento de Química Orgânica, Instituto de Química, Universidade Federal da Bahia, Salvador, Brazil.
is one of the most important genera of the Clusiaceae family, comprising up to 400 species. This review describes the identification of twenty-two flavonoids from species, which includes five flavonols ( and ), six flavones (), one catechin (), one flavanone (), and nine biflavonoids (). O- and C-glycosylation are frequently observed amongst these flavonoids.
View Article and Find Full Text PDFBioorg Chem
April 2024
Department of Food Science, Graduate School of Technology, Industrial and Social Sciences, Tokushima University, 2-1, Minamijosan-jima, Tokushima 770-8513, Japan. Electronic address:
Human serum albumin (HSA) is a serum protein that carries flavonoids in blood circulation. In this report, the binding selectivity and strength of interactions to HSA-binding sites (sites I or II) by flavonoids were evaluated using competition experiments and the specific fluorescent dyes, dansylamide and BD140. Most tested flavonoids bound site I preferentially, with the binding strength dependent on the mother structure in the order flavonol > flavone > flavanone > flavan 3-ols.
View Article and Find Full Text PDFPhytochemistry
November 2022
Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, New South Wales, Australia. Electronic address:
Prenylated and hydroxyprenylated piceatannol, resveratrol and pinosylvin derivatives were isolated from resin produced by three Australian Lepidosperma Labill. Species (Cyperaceae). From L.
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