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Signs of Hyperinflation and Ventilation Heterogeneity in Individuals With Severe Alpha-1-Antitrypsin Deficiency at the Age of 42.
Int J Chron Obstruct Pulmon Dis
March 2025
Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden, Lund University, Lund, Sweden.
Background: Severe alpha-1-antitrypsin deficiency (AATD) is a known risk factor for early development of emphysema and COPD. By the Swedish national screening program within the years 1972-74 a cohort of individuals with severe AATD (PiZZ) was identified and regularly followed up. The aim of this study was to investigate alveolar volume (V) and the ratio V/Total lung capacity (V/TLC) for the detection of signs of hyperinflation and ventilation heterogeneity in PiZZ individuals compared with an age-matched control group (phenotype PiMM), randomly selected from the population registry.
View Article and Find Full Text PDFThe effect of respiratory motion compensation in intracardiac 4D flow magnetic resonance imaging on left ventricular flow dynamics, multicomponent particle tracing, and valve tracking.
Eur Heart J Imaging Methods Pract
January 2025
Department of Radiology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
Aims: 4D flow magnetic resonance imaging (MRI) has enabled evaluation of intracardiac flow dynamics by particle tracing for visualizing and quantifying complex flow patterns. The aim of this study was to assess the impact of respiratory motion compensation on 4D flow MRI-based left ventricular four-component particle tracing, valve tracking, and haemodynamics.
Methods And Results: In this prospective cohort study, 4D flow MRI with and without respiratory motion compensation was performed in 15 healthy volunteers.
Custom-Made Mouthguard: Personalized Solution for Injury Prevention Secondary to Bruxism During Physical Activity.
Dent Traumatol
March 2025
Department of Restorative Dentistry, Federal University of Ceará, Fortaleza, Brazil.
The natural dynamics of the jaw during physical activity and its physiological mechanisms are not fully understood. However, teeth clenching during certain sports activities may be associated with increased strength, power, flexibility, and performance. This behavior is termed awake bruxism (AB) and can lead to intraoral damage, highlighting the importance of patient education and management.
View Article and Find Full Text PDFAtrial Fibrillation as a Predictor of Age-Related Macular Degeneration.
J Cardiovasc Electrophysiol
March 2025
Intermountain Medical Center Heart Institute, Intermountain Medical Center, Salt Lake City, Utah, USA.
Background: Aging of the population has resulted in more patients living with atrial fibrillation (AF) and age-related macular degeneration (AMD). AF is associated with macro- and micro-thromboembolism, microvascular dysfunction, and system inflammation. Organ systems sensitive to the long-term systemic and vascular disease associations of AF will likely develop dysfunction over time.
View Article and Find Full Text PDFWe present a 67-year-old woman with a history of coronary artery bypass graft surgery, who experienced recent chest pain. Myocardial perfusion imaging and 99mTc-FAPI-46 SPECT were performed to assess myocardial infarction. The dynamic FAPI imaging indicated sustained myocardial activity.
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