Topology identification of stochastic complex networks is an important topic in network science. In modern identification techniques under a continuous framework, the controller has a negative dynamic gain (feedback gain), such that stochastic LaSalle's invariance principle (SLIP) is directly satisfied. In this article, the topology identification of stochastic complex networks is studied under aperiodic intermittent control (AIC). It is noteworthy that the AIC has a rest time, which indicates the SLIP is not valid since there is no negative feedback gained during this period. This motivates us to find other methods to obtain identification criteria. In this study, the graph-theoretic method and the stochastic analysis technique are integrated to obtain the almost surely exponential synchronization of drive-response networks. Furthermore, this integration enables the topology identification criteria of the drive network to be derived, which differs from previous work that directly utilized SLIP. It is worth mentioning that the topology identification criteria under the stochastic framework are first proposed based on the AIC in this work. The control strategy not only reduces the control cost but also makes it easier to operate. To enhance the application value of the network model, regime-switching diffusions, multiple weights, and nonlinear couplings are simultaneously considered. Finally, the proposed identification criteria are tested by using neural networks. At the same time, the validity of the theoretical results is further proved by numerical simulations.
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http://dx.doi.org/10.1109/TNNLS.2025.3542505 | DOI Listing |
PLoS One
March 2025
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Gardnerella vaginalis is the most frequently identified bacterium in approximately 95% of bacterial vaginosis (BV) cases. This species often exhibits resistance to multiple antibiotics, posing challenges for treatment. Therefore, there is an urgent need to develop and explore alternative therapeutic strategies for managing bacterial vaginosis.
View Article and Find Full Text PDFRSC Med Chem
February 2025
Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology Groene Loper 3 5612 AE Eindhoven The Netherlands
Protein-protein interactions (PPIs) are key regulators of various cellular processes. Modulating PPIs with small molecules has gained increasing attention in drug discovery, particularly targeting the 14-3-3 protein family, which interacts with several hundred client proteins and plays a central role in cellular networks. However, targeting a specific PPI of the hub protein 14-3-3, with its plethora of potential client proteins, poses a significant selectivity challenge.
View Article and Find Full Text PDFIEEE Trans Neural Netw Learn Syst
March 2025
Topology identification of stochastic complex networks is an important topic in network science. In modern identification techniques under a continuous framework, the controller has a negative dynamic gain (feedback gain), such that stochastic LaSalle's invariance principle (SLIP) is directly satisfied. In this article, the topology identification of stochastic complex networks is studied under aperiodic intermittent control (AIC).
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