Aims: This study aimed to develop microparticles of N-phenyl-2,2-dichloroacetamide (PDA), a chloramphenicol derivative with potential antibacterial and anticancer properties, to improve drug release and selectivity while reducing toxicity.
Materials & Methods: PDA microparticles were prepared via spray-drying using L-leucine, Trehalose, and Mannitol. The particles were characterized for size, drug release, antibacterial activity, and cytotoxicity against A549 cancer cells and fibroblasts.
Results: PDA formulations exhibited controlled release and enhanced selectivity for cancer cells. S1 showed antibacterial activity against S. aureus. L-leucine formulations had reduced toxicity to normal fibroblasts.
Conclusions: PDA microparticles offer potential as safer, targeted antibacterial and anticancer therapies, providing controlled release and reduced side effects.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/20415990.2025.2476928 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of chloramphenicol derivative N-phenyl 2, 2 dichloroacetamide anticancer and antibacterial properties.
Ther Deliv
March 2025
School of Pharmacy, University of Reading, Reading, UK.
Aims: This study aimed to develop microparticles of N-phenyl-2,2-dichloroacetamide (PDA), a chloramphenicol derivative with potential antibacterial and anticancer properties, to improve drug release and selectivity while reducing toxicity.
Materials & Methods: PDA microparticles were prepared via spray-drying using L-leucine, Trehalose, and Mannitol. The particles were characterized for size, drug release, antibacterial activity, and cytotoxicity against A549 cancer cells and fibroblasts.
Synergistic immunomodulatory effect of wheat/soybean/sea cucumber peptides in chloramphenicol induced immunosuppression zebrafish.
J Sci Food Agric
March 2025
College of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, China.
Background: Food-derived immunomodulatory peptides serve as vital agents in promoting health by protecting the body against pathogens. The present study focused on determining the optimal ratio for combining different peptides to form a complex that enhances immune activity in immunosuppressed zebrafish.
Results: We established a method for immunosuppression in zebrafish, discovering that treatment with 125 μg mL chloramphenicol significantly decreased the macrophage number and neutrophil fluorescence intensity.
Optimal bimetallic Au@Ag nanocuboids-based SERS sensor for label-free ultrasensitive detection of florfenicol residue in eggs.
Mikrochim Acta
March 2025
School of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, China.
A label-free surface-enhanced Raman scattering (SERS) sensor using optimal bimetallic Au@Ag nanocuboids (Au@Ag NCs) was developed for ultrasensitive detection of florfenicol residue in eggs. The Raman characteristic peaks of florfenicol detection were identified at 1145 cm and 1595 cm which were consistent with the theoretical Raman spectrum of florfenicol calculated by density functional theory. The Au@Ag NCs were optimized by changing the aspect ratio of Au nanorods and the thickness of Ag nanocuboids, achieving an enhancement factor of 1.
View Article and Find Full Text PDFPolydatin and Nicotinamide Prevent Iron Accumulation and Lipid Peroxidation in Cellular Models of Mitochondrial Diseases.
Antioxidants (Basel)
February 2025
Centro Andaluz de Biología del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), 41013 Sevilla, Spain.
Ferroptosis, an iron-dependent form of non-apoptotic cell death, is regulated by a complex network involving lipid metabolism, iron homeostasis, and the oxidative-reductive system, with iron accumulation and lipid peroxidation as key drivers. Mitochondrial dysfunction and ROS overproduction often underlie the pathogenesis of mitochondrial diseases, for which treatment options are limited, emphasizing the need for novel therapies. In this study, we investigated whether polydatin and nicotinamide could reverse ferroptosis-related pathological features in cellular models derived from patients with pathogenic variants.
View Article and Find Full Text PDFAntimicrobial Efficacy of 1,2,3-Triazole-Incorporated Indole-Pyrazolone against Drug-Resistant ESKAPE Pathogens: Design and Synthesis.
ACS Bio Med Chem Au
February 2025
Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat 388120, India.
In the current study, we report the synthesis of novel 4-((1-((1-1,2,3-triazole-4-yl)methyl)-1-indol-3-yl)methylene)-5-methyl-2-phenyl-2,4-dihydro-3-pyrazole-3-one derivatives -. The compounds were prepared through a Knoevenagel condensation reaction and copper-catalyzed azide-alkyne cycloaddition (CuAAC) Click chemistry approach. The synthesized compounds exhibited promising antimicrobial activity against both Gram-positive and Gram-negative bacteria.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!