Objective: Frankl (1963) introduced the concept of "meaning in life" (MIL) as essential for individuals' stability, a view supported by Baumeister and Hippel (2020). This study suggests that MIL restoration follows a dynamic pattern after traumatic events.
Method: We conducted a longitudinal study with 135 family members affected by the 2014 Sewol ferry disaster in South Korea, examining changes in MIL over 5 years (2015-2019). Utilizing the repeated-measures actor-partner interdependence model, we assessed the dynamic patterns of searching for MIL (SMIL) and presence of MIL (PMIL) from a dynamical systems perspective.
Results: The analysis showed that PMIL and SMIL significantly predict their stability, indicating an attractor state for each type of MIL. Notably, survivor family members exhibited a pattern where SMIL stabilization enhanced PMIL in tandem with stability in PMIL, indicating increased MIL dynamism during active meaning restoration.
Conclusions: These findings underscore MIL's critical role in life stability after an adverse life event for the bereaved and the survivors' family members. The dynamic interaction between SMIL and PMIL in family members who experienced a traumatic life event reveals more intricate dynamics in the meaning reconstruction process, highlighting MIL's importance as a potential resilience mechanism against adversities. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
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http://dx.doi.org/10.1037/tra0001882 | DOI Listing |
Cancer Discov
March 2025
University of California, San Francisco, San Francisco, CA, United States.
Historical studies performed nearly a century ago using mouse skin models identified two key steps in cancer evolution: initiation, a likely mutational event, and promotion, driven by inflammation and cell proliferation. Initiation was proposed to be permanent, with promotion as the critical rate-limiting step for cancer development. Here, we carried out whole genome sequencing to demonstrate that initiated cells with thousands of mutagen-induced mutations can persist for long periods and are not removed by cell competition or by immune intervention, thus mimicking the persistence of cells with cancer driver mutations in normal human tissues.
View Article and Find Full Text PDFAIDS Care
March 2025
Center for Behavioral and Addiction Medicine, Department of Family Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Methamphetamine use among sexual minority men (SMM) has been associated with poor ART adherence, and reduced initiation and adherence to PrEP. From May 2021 to May 2023, 226 SMM were enrolled in , a culturally responsive smartphone application to reduce methamphetamine use and improve sexual health. Using a status-neutral approach, an ordinal variable reflected participants' placement on the HIV Prevention/Care Continuum, from HIV-positive, not taking ART, to HIV-negative, currently taking PrEP.
View Article and Find Full Text PDFAm J Public Health
April 2025
Shoshana V. Aronowitz is with the Department of Family and Community Health, University of Pennsylvania School of Nursing, Philadelphia, PA. Megan K. Reed is with the Department of Emergency Medicine and the Center for Connected Care at Sidney Kimmel Medical College, and the College of Population Health, Thomas Jefferson University, Philadelphia.
PLoS One
March 2025
Public Health Research Center, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates.
Introduction: Family history of cardiovascular disease (CVD) is an independent risk factor for coronary heart disease, and the risk increases with number of family members affected. It offers insights into shared genetic, environmental and lifestyle factors that influence heart disease risk. In this study, we aimed to estimate the association of family history of CVD and its risk factors, as well as the number of affected parents or siblings, with the prevalence of major cardiometabolic risk factors (CRFs) such as hypertension, dysglycemia, dyslipidemia and obesity in a sample of young adults.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
March 2025
University of Eastern Finland, Deaprtment of Chemistry, Yliopistokatu 7, 80101, Joensuu, FINLAND.
We studied a family of coordination compounds with short intramolecular spatial separation between an organic chromophore and a metal centre. The specific geometry was realized by means of anthracene-functionalized tertiary aryl phosphanes. Their silver and gold complexes (1, 2) operate as conventional fluorophores, with photophysical behavior defined by anthracene-localized allowed transitions.
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