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Does plasma exchange have a role in ANCA-associated vasculitis? Viewpoint 1: plasma exchange should not be used indiscriminately.
Rheumatology (Oxford)
March 2025
Department of Medicine, McMaster University, Hamilton, ON, Canada.
ANCA-associated vasculitis (AAV) is a heterogeneous autoimmune disease marked by varying organ involvement and outcomes. Plasma exchange, a method of removing native plasma and replacing it with crystalloid, albumin or donor plasma, can deplete autoantibodies and may help control autoimmune diseases rapidly. In AAV, several randomized controlled trials have been performed but, individually, had mixed results.
View Article and Find Full Text PDFDoes plasma exchange have a role in ANCA-associated vasculitis? Viewpoint 2: plasma exchange may be useful under some circumstances.
Rheumatology (Oxford)
March 2025
Department of Nephrology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
The use of plasma exchange (PLEX) as adjunct therapy in the initial management of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis remains to be discussed controversially in light of present evidence. In our Viewpoint we highlight scenarios where we think that physicians might still consider the use of PLEX, such as the most severe presentation forms including diffuse alveolar haemorrhage (DAH) with hypoxaemia and acute glomerulonephritis with significantly impaired kidney function. Recent sub-analyses of the PEXIVAS trial have focused on these patient populations and have provided outcomes of these patients.
View Article and Find Full Text PDFBackground: Historically, extracorporeal blood purification (EBP) treatment for sepsis was mainly used as an adjunctive therapy for the management of multiple organ failure rather than targeting the removal of toxins from the body that are contributing to the disease state. Approximately 10-15% of sepsis, or approximately one third to half of patients with septic shock, exhibit high levels of endotoxin activity in their blood. Humans are exquisitely sensitive to endotoxin making endotoxic septic shock (ESS) particularly deadly.
View Article and Find Full Text PDFStudy on the quality characteristics of jujube slices under different pretreatment and drying methods.
Ultrason Sonochem
March 2025
College of Food Science & Biology, Hebei University of Science & Technology, Shijiazhuang 050018, China; Hebei Provincial Functional Food Technology Innovation Center, Shijiazhuang 050018, China. Electronic address:
This study investigates the effects of different pretreatment methods, cold plasma (CP) and ultrasound (US), as well as different drying techniques, including vacuum freeze-drying (FD), hot air drying (HAD), and microwave coupled with pulsed vacuum drying (MPVD), on the quality characteristics of winter jujube slices. The physical, chemical, and functional properties were analyzed, encompassing farinograph attributes, particle size, cation exchange capacity, total phenolic and flavonoid content, and flavor compounds were analyzed. In terms of physical properties, jujube slices subjected to MPVD demonstrate superior water-holding capacity at 2.
View Article and Find Full Text PDFSevere Amiodarone-Induced Thyrotoxicosis in 2 Patients Who Required Plasmapheresis Before Thyroidectomy.
JCEM Case Rep
March 2025
Department of Endocrine Surgery, CH Epicura, Hornu 7301, Belgium.
Amiodarone is a class III antiarrhythmic medication known for its complex interplay with thyroid physiology. Its prolonged half-life can result in persistent effects on thyroid function even after discontinuation. Amiodarone-induced thyrotoxicosis (AIT) is a serious and challenging complication due to these lasting effects.
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