Since 2022, an steeply increase has been seen in the number of gonorrhea infections in the Netherlands: in 2023 in the sexual heath centra 31% more cases were found, especially among groups where this is less obvious, such as high educated young women. Gonorrhea infections can be seen with the classic symptoms of an urethritis (the drip). But also asymptomatic or in more severe ways and in different locations. In this clinical lesson we provide 3 examples of gonorrhea infections in young women. In neighboring countries, increasing resistance is being observed for ceftriaxone, the first-choice antibiotic to treat gonorrhea. For adequate treatment and to break the infection chain complete microbiological diagnostics or a test of cure can be necessary. The article ends with prevention measures: condom use and effective partner notification.
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Comput Struct Biotechnol J
February 2025
School of Pharmacy and Biomedical Science, University of Waikato, Hamilton 3216, New Zealand.
is an obligate human pathogen and the etiological agent of the sexually transmitted infection, gonorrhoea. The rapid emergence of extensively antimicrobial-resistant strains, including those resistant to all frontline antibiotics, has led to being labelled a priority pathogen by the World Health Organization, highlighting the need for new antimicrobial treatments. Given its absence in humans, targeting cysteine biosynthesis has been identified as a promising avenue for developing new antimicrobials against bacterial pathogens.
View Article and Find Full Text PDFClin Infect Dis
March 2025
Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States.
Doxy-PEP is used to prevent chlamydia, syphilis and gonorrhea infections in sexual and gender minority men and transgender women. We describe a systematic process for developing algorithms that allow for the identification of doxy-PEP prescriptions. Using an identified algorithm will allow for improved monitoring of implementation and effectiveness.
View Article and Find Full Text PDFNed Tijdschr Geneeskd
March 2025
RIVM, Bilthoven. Centrum Infectieziektebestrijding (CIb).
Since 2022, an steeply increase has been seen in the number of gonorrhea infections in the Netherlands: in 2023 in the sexual heath centra 31% more cases were found, especially among groups where this is less obvious, such as high educated young women. Gonorrhea infections can be seen with the classic symptoms of an urethritis (the drip). But also asymptomatic or in more severe ways and in different locations.
View Article and Find Full Text PDFSex Transm Infect
March 2025
NHS Lothian, Edinburgh, UK.
Objectives: Describe the clinical, phenotypic and genomic characteristics of ceftriaxone-resistant from Scotland.
Methods: Cases were identified in routine care from 2018 to 2024. Minimum inhibitory concentrations were determined for seven antimicrobial agents.
Taiwan J Obstet Gynecol
March 2025
Department of Obstetrics and Gynecology, Busan Paik Hospital, Inje University, College of Medicine, South Korea.
Objective: Pelvic inflammatory disease (PID) is an infection of female reproductive organs mainly in sexually active patients, which can cause serious complications throughout life. We aimed to analyze the risk factors and differences in sexually transmitted infections (STIs) between adolescents and adult PID patients.
Materials And Methods: We conducted a retrospective study based on descriptive and statistical analyses of the clinical records of patients with PID treated with antibiotics between January 2013 and December 2023 at Busan Paik Hospital.
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