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Identification and validation of transcriptome-wide association study-derived genes as potential druggable targets for osteoarthritis.
Bone Joint Res
March 2025
Department of Orthopedics, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou, China.
Aims: Osteoarthritis (OA) is a widespread chronic degenerative joint disease with an increasing global impact. The pathogenesis of OA involves complex interactions between genetic and environmental factors. Despite this, the specific genetic mechanisms underlying OA remain only partially understood, hindering the development of targeted therapeutic strategies.
View Article and Find Full Text PDFExploring the impact of RPN1 on tumorigenesis and immune response in cancer.
FASEB J
March 2025
Department of Oncology, The Central Hospital of Yongzhou, Yongzhou, Hunan, China.
The ribophorin family, including RPN1, has been associated with tumor progression, but its specific role in pan-cancer dynamics remains unclear. Using data from TCGA, GTEx, and Ualcan databases, we investigated the relationship of RPN1 with prognosis, genomic alterations, and epigenetic modifications across various cancers. Differential analysis revealed elevated RPN1 expression in multiple cancer types, indicating a potential prognostic value.
View Article and Find Full Text PDFProtective effects of Paeonia suffruticosa callus extract in skin through anti-inflammation and repair UVB-induced damage.
Int J Cosmet Sci
March 2025
Hangzhou Shiguang Xinya Biotechnology Co., Ltd., Hangzhou, China.
Objective: The study investigated effects of peony callus extracts (PCE) on the protective efficacy against Ultraviolet B (UVB)-induced photoageing, using in vitro and in vivo studies. The research focused on PCE's ability to protect against inflammatory factors, DNA damage and accumulation of senescent cells, along with the evaluation of the extract's potential anti-photoageing benefits to skin.
Methods: Human keratinocyte cell line (HaCaT cells), mast cells and fibroblasts were used to evaluate the role of PCE in anti-photoageing.
Medication experiences in the treatment of opioid use disorders: Insights from Reddit.
Addiction
March 2025
Division of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, CA, USA.
Background And Aims: Better understanding the challenges faced by patients on medications for opioid use disorder (MOUD), including methadone and buprenorphine, is critical to increasing their use/retention. Social media platforms such as Reddit offer a space for patients to share their experiences with medications. We aimed to identify and characterize challenges faced by patients taking MOUD through analysis of discussions from the r/Methadone and r/suboxone subreddits.
View Article and Find Full Text PDFBiological Activity of Biomarkers Associated With Metastasis in Osteosarcoma Cell Lines.
Cancer Med
March 2025
Universidad Autónoma del Estado de Morelos, Facultad de Medicina, Cuernavaca, Morelos, Mexico.
Introduction: Osteosarcoma, a highly aggressive bone cancer primarily affecting children and young adults, remains a significant challenge in clinical oncology. Metastasis stands as the primary cause of mortality in osteosarcoma patients. However, the mechanisms driving this process remain incompletely understood.
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