Gastric cancer (GC) is the result of a convoluted series of incidents that include host genetic susceptibility, Helicobacter pylori infection, and other external influences. The emergence of many hereditary and chromatin modifications in carcinogenic and tumor-inhibiting genes results in the disruption of several molecular networks, upsetting the balance between cell proliferation and apoptosis as well as the cell cycle. Important roles are played by members of the Toll-like receptor (TLR) family in both native and adaptive immunological reactions. The owner can identify various pathogen-associated molecular patterns (PAMPs) with the TLR proteins, including DNA carrying CPG, viral RNA, and bacterial lipopolysaccharides. Moreover, the TLRs detect molecular patterns associated with danger, which have been connected to a number GC. According to different concepts, TLRs are expressed by both immunological and malignant cells. The several roles that TLRs play in GC were compiled in this review paper.
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