Brain tumor is categorized as one of the most fatal form of cancer due to its location and difficulty in terms of diagnostics. Medical expert relies on two key approaches which include biopsy and MRI. However, these techniques have several setbacks which include the need of medical experts, inaccuracy, miss-diagnosis as a result of anxiety or workload which may lead to patient morbidity and mortality. This opens a gap for the need of precise diagnosis and staging to guide appropriate clinical decisions. In this study, we proposed the application of deep learning (DL)-based techniques for the classification of MRI vs non-MRI and tumor vs no tumor. In order to accurately discriminate between classes, we acquired brain tumor multimodal image (CT and MRI) datasets, which comprises of 9616 MRI and CT scans in which 8000 are selected for discrimination between MRI and non-MRI and 4000 for the discrimination between tumor and no tumor cases. The acquired images undergo image pre-processing, data split, data augmentation and model training. The images are trained using 4 DL networks which include MobileNetV2, ResNet, Ineptionv3 and VGG16. Performance evaluation of the DL architectures and comparative analysis has shown that pre-trained MobileNetV2 achieved the best result across all metrics with 99.94% accuracy for the discrimination between MRI and non-MRI and 99.00% for the discrimination between tumor and no tumor. Moreover, I-BrainNet which is a DL/IoT-based framework is developed for the real-time classification of brain tumor.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1007/s10278-025-01470-1 | DOI Listing |
Adv Healthc Mater
March 2025
Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor, characterized by its heterogeneity in cellular components, including reactive astrocytes and microglia. Since neuroimmune responses like astrogliosis and microgliosis gain recognition as vital factors in brain tumor progression, there is a growing need for clinically relevant models that assess the interactions between astrocytes, microglia, and GBM. Here, a NEuroimmune-Oncology Microphysiological Analysis Platform (NEO-MAP) is presented as a "new map" to observe astrocytic scar formation and microgliosis in response to GBM.
View Article and Find Full Text PDFRadiol Artif Intell
March 2025
Department of Radiology, Duke University Hospital, 2301 Erwin Rd, Durham, NC 27710.
Purpose To develop and evaluate an automated system for extracting structured clinical information from unstructured radiology and pathology reports using open-weights language models (LMs) and retrieval augmented generation (RAG) and to assess the effects of model configuration variables on extraction performance. Materials and Methods This retrospective study utilized two datasets: 7,294 radiology reports annotated for Brain Tumor Reporting and Data System (BT-RADS) scores and 2,154 pathology reports annotated for mutation status (January 2017 to July 2021). An automated pipeline was developed to benchmark the performance of various LMs and RAG configurations for structured data extraction accuracy from reports.
View Article and Find Full Text PDFCells
February 2025
Fiona Elsey Cancer Research Institute, Ballarat, VIC 3350, Australia.
Several immunoregulatory or immune checkpoint receptors including T cell immunoglobulin and mucin domain 3 (TIM-3) have been implicated in glioblastoma progression. Rigorous investigation over the last decade has elucidated TIM-3 as a key player in inhibiting immune cell activation and several key associated molecules have been identified both upstream and downstream that mediate immune cell dysfunction mechanistically. However, despite several reviews being published on other immune checkpoint molecules such as PD-1 and CTLA-4 in the glioblastoma setting, no such extensive review exists that specifically focuses on the role of TIM-3 in glioblastoma progression and immunosuppression.
View Article and Find Full Text PDFCell Prolif
March 2025
Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Glioblastoma multiforme (GBM) is the deadliest brain tumour with an extremely poor prognosis. Tryptophan catabolism could enhance an array of protumour-genic signals and promoted tumour progression in GBM. However, the mechanisms of oncogenic signalling under tryptophan catabolism and potential therapy targeting this pathway have not been completely understood.
View Article and Find Full Text PDFActas Esp Psiquiatr
March 2025
Graduate School, Harbin Sport University, 150008 Harbin, Heilongjiang, China; Department of Rehabilitation Medicine, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, 150000 Harbin, Heilongjiang, China.
Background: Neuroinflammation and neurogenic disorders lead to depression in stroke patients. As, exercise intervention, a non-drug therapy, has been proven effective in post-stroke depression (PSD) patients. However, the underlying molecular mechanism by which exercise improves PSD still needs to be explored.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!