Background: Transtricuspid cardiac implantable electronic devices (CIEDs) complicate the management of tricuspid regurgitation (TR). Transcatheter tricuspid valve annuloplasty (TTVA) offers a promising approach due to minimal interaction with leaflets and transvalvular CIEDs, though real-world evidence is limited.
Methods: This bi-center, retrospective study includes 204 consecutive patients who underwent TTVA with the Cardioband (Edwards Lifesciences) for severe symptomatic TR. Patients were divided into CIED carriers and non-CIED carriers. CIED carriers were further classified into those with lead-associated TR (LTR-A) and those with TR unrelated to CIED leads (LTR-B).
Results: Among the 204 patients, 41 (20%) were CIED carriers. Of these, 24% had mixed TR etiology (functional and LTR-A), while 76% had predominantly functional TR (LTR-B). Compared to non-CIED-carriers, CIED carriers were more symptomatic (NYHA-FC > II; 93% vs. 89%; p = 0.026) with comparable TR severity at baseline. Intraprocedural success according to the Tricuspid Valve Academic Research Consortium was 68% in CIED carriers and 70% in non-CIED carriers (p = 0.851). LTR-A was associated with poorer TR reduction immediately after TTVA (p = 0.022). Overall safety was comparable, with right ventricular lead dislodgement occurring in one patient. Beyond that, CIED function remained unimpaired. At 30 days, echocardiographic follow-up showed comparable TR reduction (TR ≤ II: 56% vs. 68%; p = 0.219) and NYHA-FU ≤ II (63% vs. 70%; p = 0.524) in CIED-and non-CIED carriers, respectively.
Conclusions: TTVA achieves significant TR reduction, providing a safe and effective therapeutic option for TR treatment in CIED carriers. WHAT IS KNOWN?: TTVA using the Cardioband has been approved for severe, symptomatic TR patients, however data on the safety and efficacy in CIED carriers is lacking. WHAT THE STUDY ADDS?: Intraprocedural success and safety were comparable in CIED and non-CIED carriers treated with TTVA. Subgroup analyses showed a trend towards worse outcome and efficiency of TTVA in patients with LTR-A. Postinterventional CIED interrogations did not show critical technical issues.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00392-025-02616-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cardiac implantable electronic device carriers undergoing transcatheter tricuspid valve annuloplasty: real-world insights.
Clin Res Cardiol
March 2025
Heart Center, Department III of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany.
Background: Transtricuspid cardiac implantable electronic devices (CIEDs) complicate the management of tricuspid regurgitation (TR). Transcatheter tricuspid valve annuloplasty (TTVA) offers a promising approach due to minimal interaction with leaflets and transvalvular CIEDs, though real-world evidence is limited.
Methods: This bi-center, retrospective study includes 204 consecutive patients who underwent TTVA with the Cardioband (Edwards Lifesciences) for severe symptomatic TR.
Multicentric Experience With the Use of Short 13Fr Mechanical Rotating Dilator Sheath for Transvenous Lead Extraction.
Pacing Clin Electrophysiol
February 2025
De Gasperis Cardio Center, Electrophysiology Unit, Niguarda Hospital, Milan, Italy.
Background: The need for transvenous lead extraction (TLE) is increasing worldwide. Since the course of the subclavian vein until the junction with the superior vena cava is a frequent place of lead adherences, we aim to assess the safety and efficacy of a short 13Fr bidirectional rotational mechanical sheath as first choice.
Methods And Results: In this multicentric study, 202 carriers of a cardiac implantable electronic device (CIED) undergoing TLE using a short 13 Fr bidirectional rotational mechanical sheath were prospectively enrolled.
Incidence of Bacteremia in Patients Following Implantation of Cardiac Implantable Electronic Devices: A Danish Nationwide Cohort Study.
Open Forum Infect Dis
September 2024
Department of Cardiology, Zealand University Hospital, Roskilde, Denmark.
Article Synopsis
- Bacteremia (SAB) is a serious condition that can lead to high rates of illness and death, especially in patients with cardiac implantable electronic devices (CIEDs), prompting researchers to study its incidence in first-time CIED carriers in Denmark over a 10-year period.
- The study involved 87,257 patients from a national registry who had their first CIED implanted from 2000 to 2020, with a focus on identifying the occurrence of SAB after the procedure and understanding risk factors that contribute to it.
- Results showed that 1.6% of patients developed SAB, with higher risks associated with specific device types and factors such as hemodialysis, previous SAB, liver disease, and demographic
Forensic perspectives on postmortem CIED interrogation: A systematic review and meta-analysis.
Forensic Sci Int
June 2024
Department of Excellence of Biomedical Science and Public Health - Section of Legal Medicine - University Politecnica delle Marche of Ancona, Via Tronto 10/A, Ancona, Italy. Electronic address:
Article Synopsis
- * Researchers analyzed 25 studies involving 3,194 decedents with CIEDs, focusing on the rates of postmortem interrogation and autopsy outcomes, as well as the final rhythms detected and their implications for determining cause and time of death.
- * Findings revealed a high postmortem interrogation success rate (89%) but significant variability across studies, with 24% of CIED carriers experiencing sudden cardiac death, highlighting the importance of these devices in forensic contexts.
Activated rate-response is associated with increased mortality risk in cardiac device carriers with acute heart failure.
PLoS One
April 2024
Dept. of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany.
Aims: This study investigated whether an activated R-mode in patients carrying a cardiac implantable electronic device (CIED) is associated with worse prognosis during and after an episode of acutely decompensated heart failure (AHF).
Methods: Six hundred and twenty-three patients participating in an ongoing prospective cohort study that phenotypes and follows patients admitted for AHF were studied. We compared CIED carriers with activated R-mode stimulation (CIED-R) to CIED carriers not in R-mode (CIED-0) and patients without CIEDs (no-CIED).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!