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Prevention of pneumococcal infections: Impact of structured medico-pharmaceutical collaborative management to improve vaccination coverage of at-risk patients (OPTIVACC study): Protocol for a multicenter randomized stepped -wedge study.
Contemp Clin Trials Commun
April 2025
Department of Pharmacy, Nimes University Hospital, Univ Montpellier, Nimes, France.
Background: causes infections especially in patients with immunodeficiency or specific comorbidities. Most could be avoided through pneumococcal vaccination (PV), but PV coverage is only 20 % in France. Many studies assess methods on vaccination coverage improvement, but none evaluates pharmacist-physician collaboration in hospital on PV coverage of inpatients at-risk of invasive pneumococcal disease (IPD).
View Article and Find Full Text PDFWhat Is a Stepped-Wedge Cluster Randomized Trial?
JAMA Intern Med
March 2025
Department of Biostatistics, School of Public Health, University of Washington, Seattle.
Detection of cognitive impairment, dementia and associated risk factors among Aboriginal and Torres Strait Islander peoples: Retrospective baseline audit results from a stepped-wedge cluster-randomised controlled trial.
Australas J Ageing
March 2025
The University of Melbourne, Faculty of Medicine, Dentistry and Health Sciences, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Objective: Aboriginal and Torres Strait Islander peoples experience high rates of dementia, cognitive impairment not dementia (CIND) and associated risk factors. The objective of this paper is to outline baseline audit results of documented dementia, CIND and associated risk factors in patients attending Aboriginal Community-Controlled Health Organisations (ACCHOs).
Methods: Twelve ACCHOs in urban, regional and remote locations across Queensland, New South Wales, Victoria and Western Australia participated in the study.
Can the use of a next generation partograph based on WHO's latest intrapartum care recommendations improve neonatal outcomes? (PICRINO) Study protocol for a stepped-wedge cluster randomized trial.
PLoS One
March 2025
Department of Obstetrics and Gynecology, Linköping University, Linköping, Sweden.
Background: Monitoring labor and childbirth, early recognition, and treatment of complications are critical for preventing adverse birth outcomes. However excessive use of interventions during labor has not been demonstrated to enhance subsequent birth outcomes and may, in fact, pose a risk of harm. The World Health Organization has recently synthesized research from the last decade concerning labor progress and patient-centered care into a new recommendation: the Labour Care Guide (LCG).
View Article and Find Full Text PDFImpact of a smartphone application for appropriate antibiotic prescribing at three tertiary hospitals; an international, multicentre stepped-wedge cluster randomised trial.
Clin Microbiol Infect
March 2025
Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands.
Objectives: Smartphone applications (apps) for antibiotic prescribing have been studied in observational studies. Here, we assessed whether use of a smartphone app increased appropriateness of antibiotic therapy (AAT) in hospitals.
Methods: An antibiotic stewardship app (Firstline.
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