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FcrX coordinates cell cycle and division during free-living growth and symbiosis by a ClpXP-dependent mechanism.
Proc Natl Acad Sci U S A
March 2025
Commissariat à l'énergie atomique et aux énergies alternatives, CNRS, Institute for Integrative Biology of the Cell, Université Paris-Saclay, Gif-sur-Yvette 91198, France.
is a soil bacterium that establishes a nitrogen-fixing symbiosis within root nodules of legumes. In this symbiosis, undergoes a drastic cellular change leading to a terminally differentiated form, called bacteroid, characterized by genome endoreduplication, increased cell size, and high membrane permeability. Bacterial cell cycle (mis)regulation is at the heart of this differentiation process.
View Article and Find Full Text PDFCharacterization of diverse Cas9 orthologs for genome and epigenome editing.
Proc Natl Acad Sci U S A
March 2025
Department of Biomedical Engineering, and Center for Advanced Genomic Technologies, Duke University, Durham, NC 27708.
CRISPR-Cas9 systems have revolutionized biotechnology, creating diverse new opportunities for biomedical research and therapeutic genome and epigenome editing. Despite the abundance of bacterial CRISPR-Cas9 systems, relatively few are effective in human cells, limiting the overall potential of CRISPR technology. To expand the CRISPR-Cas toolbox, we characterized a set of type II CRISPR-Cas9 systems from select bacterial genera and species encoding diverse Cas9s.
View Article and Find Full Text PDFCombatting antibiotic resistance in Gardnerella vaginalis: A comparative in silico investigation for drug target identification.
PLoS One
March 2025
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Gardnerella vaginalis is the most frequently identified bacterium in approximately 95% of bacterial vaginosis (BV) cases. This species often exhibits resistance to multiple antibiotics, posing challenges for treatment. Therefore, there is an urgent need to develop and explore alternative therapeutic strategies for managing bacterial vaginosis.
View Article and Find Full Text PDFMendelian randomization and mediation analysis reveal the role of immune cell subsets in the causal pathways between blood cell perturbation responses and rheumatoid arthritis.
Clin Rheumatol
March 2025
Laboratory of Human Anatomy, School of Basic Medicine Anatomy , Southwest Medical University, Xianglin Road, Longmatan District, Luzhou City, Sichuan Province, China.
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by complex immune interactions. Elucidating the causal relationships between blood cell perturbations, immune cell subsets, and RA can provide valuable insights into its pathogenesis.
Methods: This study employed bidirectional two-sample Mendelian Randomization (MR) to explore the causal effects of blood cell perturbations on RA risk, with a focus on immune cell mediation.
The C24-methyl/ethyl sterol ratio is increased by Rhizophagus irregularis colonization.
Mycorrhiza
March 2025
INRAE, Institut Agro Dijon, Université de Bourgogne, Agroécologie, Dijon, France.
Plant-microorganism interactions underlie many ecosystem roles, in particular the enhancement of plant nutrition through mutualistic relationships, such as the arbuscular mycorrhizal symbiosis that affects a large proportion of land plants. The establishment of this interaction induces a wide range of signaling pathways in which lipids, and particularly sterols, may play a central role. However, their supported functions are poorly known.
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