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The role of endomyocardial biopsy for surveillance of cardiac allograft rejection: time to move on?
Cardiol J
March 2025
Cardiology Department, Hospital General Universitario Gregorio Marañon, Faculty of Medicine, Universidad Complutense de Madrid and CIBERCV, Madrid, Spain.
The cellular and molecular cardiac tissue responses in human inflammatory cardiomyopathies after SARS-CoV-2 infection and COVID-19 vaccination.
Nat Cardiovasc Res
February 2025
DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany.
Myocarditis, characterized by inflammatory cell infiltration, can have multiple etiologies, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or, rarely, mRNA-based coronavirus disease 2019 (COVID-19) vaccination. The underlying cellular and molecular mechanisms remain poorly understood. In this study, we performed single-nucleus RNA sequencing on left ventricular endomyocardial biopsies from patients with myocarditis unrelated to COVID-19 (Non-COVID-19), after SARS-CoV-2 infection (Post-COVID-19) and after COVID-19 vaccination (Post-Vaccination).
View Article and Find Full Text PDFInflammation clashing onto myocardial susceptibility: a tale of two rare diseases-a case report.
Eur Heart J Case Rep
February 2025
Cardiology Department, Hospital de Santa Cruz, Avenida Prof. Dr. Reinaldo dos Santos, 2790-134 Lisbon, Portugal.
Background: Sarcoidosis is a rare inflammatory disease characterized by the presence of myocardial non-caseating granulomas. Heart failure, conduction abnormalities, and/or life-threatening arrhythmias are the main manifestations of cardiac sarcoidosis (CS). Cardiac magnetic resonance plays a major role in the diagnostic suspicion of cardiac involvement in sarcoidosis.
View Article and Find Full Text PDFHow do serum cytokine levels change in myocarditis and inflammatory dilated cardiomyopathy relative to healthy individuals? A protocol for a systematic review and meta-analysis.
BMJ Open
February 2025
Department of Histology and Cell Pathology, Medical University of Silesia, Zabrze, Poland.
Introduction: Myocarditis is an inflammatory heart disease resulting from infections, toxic exposures or autoimmune reactions. Irrespective of the factors responsible for this disease, cytokines play an important role in regulating the immunological response involved in its development and progression. Accordingly, this protocol aims to conduct a systematic review and meta-analysis summarising previous research on serum and plasma levels of cytokines in patients with myocarditis and inflammatory dilated cardiomyopathy.
View Article and Find Full Text PDFCardiac Amyloidosis: A Comprehensive Review of Imaging Findings.
Acad Radiol
January 2025
Russell H. Morgan Department of Radiology and Radiological Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland (A.M., G.Z., A.B., I.R.K., M.U., S.L.Z.). Electronic address:
Cardiac amyloidosis is an infiltrative cardiomyopathy caused by the deposition of insoluble amyloid fibrils in the myocardium, leading to abnormal cardiac function and heart failure. Diagnosis is often challenging due to its diverse symptoms and related comorbidities. Although endomyocardial biopsy is the gold standard for diagnosis, a complete diagnostic approach often includes non-invasive methods such as Cardiac Magnetic Resonance (CMR) and nuclear medicine techniques.
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