Two near full-length sequences of vesicular stomatitis Indiana virus (VSIV), representing endemic VSIV lineages circulating in cattle in Mexico, are reported. These sequences will allow us to gain more insight into the genetic relationship between endemic viruses in Mexico and the emergence of epizootic lineages in the United States.
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Near-full-length vesicular stomatitis Indiana virus genome sequences representative of endemic strains circulating in Mexico.
Microbiol Resour Announc
March 2025
National Bio and Agro-Defense Facility (NBAF), ARS, USDA, Manhattan, Kansas, USA.
Two near full-length sequences of vesicular stomatitis Indiana virus (VSIV), representing endemic VSIV lineages circulating in cattle in Mexico, are reported. These sequences will allow us to gain more insight into the genetic relationship between endemic viruses in Mexico and the emergence of epizootic lineages in the United States.
View Article and Find Full Text PDFWe recently identified the F ACT- E TS-1 A ntiviral R esponse (FEAR) pathway as an interferon-independent innate immune response that restricts DNA virus replication and is countered by poxvirus-encoded A51R proteins (Rex , 2024, ). The human FEAR pathway is mediated by the FACT complex, consisting of hSpt16 and SSRP1 subunits, that remodels chromatin to activate expression of the antiviral transcription factor, ETS-1. To counter this pathway, poxvirus A51R proteins tether SUMOylated hSpt16 subunits to microtubules to prevent ETS-1 expression.
View Article and Find Full Text PDFUnlabelled: A panzootic of highly pathogenic avian influenza (HPAI) H5N1 viruses from clade 2.3.4.
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Adv Healthc Mater
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Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.
Trauma or inflammation-caused cartilage injury leads to joint dysfunction and pain. Exogenous hyaluronic acid (HA) injection is a well-established treatment, but it has a short duration in vivo and requires multiple injections. Here, a new strategy for in situ reprogramming chondrocytes to continuously produce endogenous high molecular weight HA is developed.
View Article and Find Full Text PDFDonor-acceptor (perylenethienyl)ethylenes as singlet oxygen-photogenerating viral inhibitors.
Chembiochem
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Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences: FBGUN Institut bioorganiceskoj himii im akademikov M M Semakina i U A Ovcinnikova Rossijskoj akademii nauk, Laboratory of Mosecular Design and Synthesis, RUSSIAN FEDERATION.
The development of broad-spectrum antiviral drugs effective against a wide variety of viruses is of significant practical importance. Derivatives of perylene, a pentacyclic aromatic hydrocarbon, demonstrate pronounced antiviral activity. These compounds primarily act as membrane-active singlet oxygen photogenerators, disrupting virions and inhibiting their fusion with a host cell membrane.
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