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LDL cholesterol levels and treatment intensity in secondary prevention of patients with ischemic heart disease in the primary care setting: a real-world data registry study.
BJGP Open
March 2025
Consorci d'Atenció Primària de Salut Barcelona Esquerra (CAPSBE), Barcelona, Spain
Background: Monitoring LDL cholesterol (LDL-C) and prescribing appropriate treatment is crucial for secondary prevention in primary care.
Aim: We studied LDL-C levels and treatments for ischemic heart disease patients according to target recommendations and assessed factors influencing prescribed drug intensity.
Design & Setting: We examined electronic health records of patients with ischemic heart disease from three primary care centers.
Effectiveness of nirsevimab in preventing RSV-hospitalisation among young children in Western Australia 2024.
J Infect
March 2025
Department of Infectious Diseases, Perth Children's Hospital, Perth, Western Australia, Australia; Wesfarmers Centre for Vaccines and Infectious Diseases, The Kids Research Institute Australia, University of Western Australia, Perth, Western Australia, Australia; School of Medicine, University of Western Australia, Perth, WA, Australia; Department of Microbiology, PathWest Laboratory Medicine, Perth, Western Australia, Australia.
Background: Respiratory Syncytial Virus (RSV) causes a significant burden of illness for children under 2 years of age. Nirsevimab, a long-acting monoclonal antibody, was registered for RSV prevention in Australia in 2023. In April 2024, Western Australia (WA) launched the country's first state-wide nirsevimab program for all infants and high-risk children entering their second RSV season.
View Article and Find Full Text PDFReal-world experience of cannabidiol in conjunction with clobazam for the treatment of seizures associated with Lennox-Gastaut syndrome and Dravet syndrome: Results from a retrospective multicentre chart review in Germany.
Epilepsy Behav
March 2025
Goethe-University Frankfurt, Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, University Hospital Frankfurt, Frankfurt am Main, Germany.
Background: Lennox-Gastaut syndrome (LGS) and Dravet syndrome (DS) are rare and debilitating forms of epilepsy, characterised by recurrent, severe, drug-resistant seizures and neurodevelopmental impairments. A non-euphoric, plant-derived, highly purified formulation of cannabidiol (CBD; Epidyolex®, 100 mg/mL oral solution) is approved in the European Union and United Kingdom for use in patients aged ≥2 years for the adjunctive treatment of seizures associated with LGS or DS in conjunction with clobazam (CLB), and for the adjunctive treatment of seizures associated with tuberous sclerosis complex in patients aged ≥2 years.
Methods: We performed a retrospective chart review of patients with treatment-resistant epilepsies who were treated with adjunctive CBD at six epilepsy centres in Germany.
Facial video based stress detection for enhancing ecological validity.
Acta Psychol (Amst)
March 2025
Chinese Academy Sciences Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. Electronic address:
In contemporary society, high-level stress poses significant detrimental effects on mental and physical well-being, impacting performance in various aspects of life including work, studies, and social interactions. Previous research efforts have primarily relied on the induction of stress through diverse mental tasks under artificial experimental conditions, which may lack ecological validity. This study aimed to address this limitation by collecting facial data without additional contextual interventions during self-introductions from participants.
View Article and Find Full Text PDFAntibiotic prescription in pediatric patients with influenza in outpatient and emergency departments: A cross-sectional study.
J Infect Public Health
March 2025
Department of Infectious Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Key Laboratory of Major Diseases in Children, Ministry of Education, Research Unit of Critical infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Beijing, China. Electronic address:
Background: Influenza is a common viral respiratory infection, and inappropriate antibiotic use may lead to increased drug resistance and unnecessary waste of healthcare resources. However, real-world antibiotic prescribing in pediatric influenza patients remains largely unknown in China.
Methods: We performed a cross-sectional study of outpatient and emergency department prescriptions in a tertiary children's hospital for pediatric patients diagnosed with influenza between January 1, 2021, and July 31, 2023.
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