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METTL7B-induced histone lactylation prevents heart failure by ameliorating cardiac remodelling.
J Mol Cell Cardiol
March 2025
Department of Cardiology, Translational Research Center for Regenerative Medicine and 3D Printing Technologies, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, China. Electronic address:
Introduction: Lactylation is important for a variety of biological activities. It is reported that Class I histone deacetylases (HDAC1-3) are histone lysine delactylases. However, the role of lactylation in cardiac remodelling remains uncertain.
View Article and Find Full Text PDFSensing the Future of Thrombosis Management: Integrating Vessel-on-a-Chip Models, Advanced Biosensors, and AI-Driven Digital Twins.
ACS Sens
March 2025
School of Biomedical Engineering, The University of Sydney,Darlington,NSW 2008,Australia.
Thrombotic events, such as strokes and deep vein thrombosis, remain a significant global health burden, with traditional diagnostic methods often failing to capture the complex, patient-specific nuances of thrombosis risk. This Perspective explores the revolutionary potential of microengineered vessel-on-chip platforms in thrombosis research and personalized medicine. We discuss the evolution from basic microfluidic channels to advanced 3D-printed, patient-specific models that accurately replicate complex vascular geometries, incorporating all elements of Virchow's triad.
View Article and Find Full Text PDFPrinting hearts: three-dimensional printing as a transformative technology in transcatheter mitral valve interventions.
Expert Rev Med Devices
March 2025
NHS Foundation Trust, King's College Hospital, London, UK.
Precise additive food manufacturing: Printing of millet dough, characterization, and comprehensive printability assessment.
J Food Sci
March 2025
Department of Food Engineering, National Institute of Food Technology Entrepreneurship and Management, Sonipat, Haryana, India.
The research aims at the development of 3D-printed millet-based composite dough cookies from a selected formulation, among 31 formulations, with the best printability and stability. The dough comprises composite pearl and amaranth millet flour in an equal ratio (20-40 g), shortening (10-30 g), jaggery (12-22 g), and water (25-35 g). In stage one, a comprehensive analytical printability assessment of printed construct in terms of printing precision, printing rate, and stability is conducted.
View Article and Find Full Text PDFGeneralizable deep learning framework for 3D medical image segmentation using limited training data.
3D Print Med
March 2025
Department of Medical Imaging and Physiology, Lund University, Lund, Sweden.
Medical image segmentation is a critical component in a wide range of clinical applications, enabling the identification and delineation of anatomical structures. This study focuses on segmentation of anatomical structures for 3D printing, virtual surgery planning, and advanced visualization such as virtual or augmented reality. Manual segmentation methods are labor-intensive and can be subjective, leading to inter-observer variability.
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