Pheochromocytoma is a rare, primarily benign tumor that arises from the chromaffin cells of the adrenal medulla. It is known for causing excessive secretion of catecholamines, such as epinephrine and norepinephrine. This condition poses significant health risks due to its potential to cause severe cardiovascular complications, including hypertension, stroke, and various forms of cardiomyopathy. A 29-year-old woman with a history of diabetes mellitus (DM) and hypertension presented with symptoms suggestive of an infection related to an intrauterine device (IUD). However, persistent symptoms following the removal of the IUD and further diagnostic evaluations revealed dilated cardiomyopathy (DCM) secondary to catecholamine excess, which led to the diagnosis of pheochromocytoma. This diagnosis was confirmed through comprehensive laboratory testing and imaging. The surgical removal of the tumor resulted in significant improvement in her cardiac function and the resolution of both hypertension and DM. This case highlights the importance of considering pheochromocytoma in the differential diagnosis of unexplained cardiac symptoms, particularly in young patients with hypertension. The varied clinical presentation can complicate the diagnosis; however, early detection and appropriate management, including surgery, can lead to complete recovery. This case also underscores the potentially reversible nature of catecholamine-induced cardiomyopathy when the underlying tumor is treated effectively.
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http://dx.doi.org/10.1002/ccr3.70241 | DOI Listing |
Syst Rev
March 2025
Department of Cardiology, Guang'Anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Background: Chinese classical prescriptions (CCPs) are commonly utilized in China as an adjuvant treatment for dilated cardiomyopathy (DCM). Nevertheless, there was insufficient systematic evidence data to show the advantages of CCPs plus current conventional therapy (CT) against DCM. This network meta-analysis (NMA) sought to evaluate and prioritize the six different CCP types' respective efficacies for DCM.
View Article and Find Full Text PDFDilated cardiomyopathy is a rare and often little-known complication of pheochromocytoma, it is likewise exceptionally its discovery circumstance. This is usually an acute, reversible cardiomyopathy.We report the case of a 20-year-old young adult hospitalized for hypokinetic dilated cardiomyopathy with severe impairment of left ventricular ejection fraction (LVEF) to 17%.
View Article and Find Full Text PDFPhytomedicine
March 2025
Department of Basic Medicine, Wuxi School of Medicine, Jiangnan University, No. 1800, Lihu Avenue, Wuxi, Jiangsu 214122, China; Department of Cardiology, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Jiangnan University, Wuxi, Jiangsu 214122, China; MOE Medical Basic Research Innovation Center for Gut Microbiota and Chronic Diseases, Wuxi School of Medicine, Jiangnan university, Wuxi, Jiangsu 214122, China. Electronic address:
Background: Doxorubicin (Dox)-induced cardiomyopathy (DIC) is characterized by severe myocardial damage that can progress to dilated cardiomyopathy and potentially lead to heart failure. No effective prevention or treatment strategies are available for DIC. Sauchinone, a diastereomeric lignan isolated from Saururus chinensis, is known for its notable anti-inflammatory effects.
View Article and Find Full Text PDFEuropace
March 2025
Nantes Université, CHU Nantes, Department of Pediatric Cardiology and Pediatric Cardiac Surgery, FHU PreciCare, F-44000 Nantes, France.
Background And Aims: The natural history of congenital or childhood non-immune, isolated atrioventricular block (AVB) is poorly defined. We aimed at clarifying its long-term outcomes.
Methods: We retrospectively studied 385 children with isolated, non-immune AVB diagnosed from in utero or up to 18 years of age, at 29 French medical centers, between 1980 and 2022.
Eur J Hum Genet
March 2025
Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden.
Pathogenic variants in the EMD gene cause X-linked Emery-Dreifuss muscular dystrophy type 1 (EDMD1), typically presenting with joint contractures and skeletal muscle atrophy, followed by atrial arrhythmias, cardiac conduction defects, and atrial dilatation. Although an association with isolated dilated cardiomyopathy (DCM) has been suggested, evidence is currently insufficient to verify the gene-disease association. We investigated the causality of a missense variant, c.
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