Continuous and non-invasive monitoring of metabolic parameters, particularly glucose and lactate, represents a critical advance in inpatient medicine where current technologies fall short. Wearable sensors are widely available for glucose, and are commonly and successfully used in ambulatory settings. More recently, wearable sensors have become available for lactate, and these devices have a proven role in exercise physiology literature. In the inpatient setting, metabolic monitoring of glucose and lactate is primarily done via invasive blood draws, which is resource-intensive and leads to delays in data collection. This new frontier of wearable continuous monitors has the potential to transform inpatient care by rapidly detecting metabolic changes and eliminating existing gaps in monitoring. Further, these advances in wearable technology open pathways for integrating lactate and glucose metrics into Early Warning Scores (EWS), enhancing their predictive capabilities. The adoption of wearable lactate and glucose in the inpatient setting has the potential to revolutionize a clinician's ability to identify vulnerable patients at risk for deterioration while guiding precision treatment.
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http://dx.doi.org/10.7759/cureus.78536 | DOI Listing |
J Pediatr Nurs
March 2025
Mustafa Kemal University, Medical Faculty, Department of Pediatric Cardiology, Hatay, Turkey.
Background: The global COVID-19 pandemic has necessitated the widespread use of N95 masks, yet their impact on children with chronic conditions like type 1 diabetes (T1DM) remains underexplored.
Objective: This study investigates the effects of N95 mask usage on clinical outcomes in children with T1DM.
Methods: This study enrolled 34 children aged 10-18 with T1DM.
Cell Biochem Biophys
March 2025
Division of Nephrology, Shanghai Pudong Hospital, Fudan University, Pudong Medical Center, Shanghai, China.
Secretory phospholipase A2 group IB (sPLA2-IB) and M-type phospholipase A2 receptor (PLA2R) are closely related to proteinuria and idiopathic membranous nephropathy (IMN). Podocytes are important components of the glomerular filtration barrier and glucose metabolism, including glycolysis and tricarboxylic acid (TCA) cycle, is crucial for maintaining podocyte physiological function. Aberrant energy metabolism has been reported in proteinuria diseases, including diabetic nephropathy.
View Article and Find Full Text PDFCirculation
March 2025
Institute of Experimental and Clinical Research (IREC), Pharmacology and Therapeutics (FATH), Cliniques Universitaires St. Luc and Université catholique de Louvain, Brussels, Belgium (L.Y.M.M., H.E., D.d.M., R.V., N.F., J.-L.B.).
Background: Cardiac β3-adrenergic receptors (ARs) are upregulated in diseased hearts and mediate antithetic effects to those of β1AR and β2AR. β3AR agonists were recently shown to protect against myocardial remodeling in preclinical studies and to improve systolic function in patients with severe heart failure. However, the underlying mechanisms remain elusive.
View Article and Find Full Text PDFFront Pharmacol
February 2025
Department of Molecular Orthopedics, Beijing Research Institute of Traumatology and Orthopedics, Beijing Jishuitan Hospital, Beijing, China.
Background: Fenvalerate (Fen) is a synthetic pyrethroid insecticide significantly associated with an increased risk of type 2 diabetes. Tumor cells exhibit a shift in glucose metabolism, known as the Warburg effect. Accordingly, we aimed to elucidate whether Fen interferes with insulin signaling and affects hepatoma cell metabolism.
View Article and Find Full Text PDFJ Transl Med
March 2025
Department of Dermatology, Children'S Hospital of Chongqing Medical University, Chongqing, 400014, China.
Background: Proliferative diabetic retinopathy (PDR) is among the primary causes of blindness in individuals with diabetes. Elevated lactate levels have been identified as a critical biomarker associated with the prognosis of PDR. While significant lactate accumulation has been observed in the vitreous fluid of PDR patients, the detailed pathways through which lactate impacts pathological neovascularization remain insufficiently elucidated.
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