Bowen's disease is a non-melanocytic in situ squamous cell carcinoma of the epidermis. Having a multifactorial etiology, its incidence has been found to be the highest in Caucasians. It commonly occurs as a solitary lesion in the elderly on the photoexposed areas of the skin, mainly in the head and neck region. We present a case of a single, pruritic, oozy ulcerated lesion in the left upper labia majora in a 32-year-old female for the last six months who had undergone various treatments before presenting to our institute. Excision followed by histopathological examination led to the diagnosis of Bowen's disease. Our case focuses on the potential of Bowen's disease to mimic common dermatological lesions, and therefore a high degree of suspicion assisted by histopathological examination is essential for early and rapid diagnosis, along with a multimodality approach to management.
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http://dx.doi.org/10.7759/cureus.78542 | DOI Listing |
Ann Vasc Surg
March 2025
Harbor UCLA Medical Center, Department of Surgery, Division of Vascular Surgery, 1000 W Carson St, Torrance CA 90502.
Background: Frailty has been reported as a predictor of adverse outcomes after various surgical procedures. There are several models for defining frailty, including 5-factor modified frailty index, clinical frailty scale, and psoas muscle index. Low psoas muscle index has been associated with higher postoperative mortality and complications after various surgical procedures.
View Article and Find Full Text PDFCureus
February 2025
Surgical Oncology, Indira Gandhi Institute of Medical Sciences, Patna, IND.
Bowen's disease is a non-melanocytic in situ squamous cell carcinoma of the epidermis. Having a multifactorial etiology, its incidence has been found to be the highest in Caucasians. It commonly occurs as a solitary lesion in the elderly on the photoexposed areas of the skin, mainly in the head and neck region.
View Article and Find Full Text PDFHealth Promot J Austr
April 2025
School of Medicine, University of Western Australia, Perth, Western Australia, Australia.
Introduction: Reflexivity is crucial for researchers and health professionals working within Aboriginal health. Reflexivity provides a tool for non-Aboriginal researchers to contribute to the broader intention of reframing historical academic positivist paradigms into Indigenous research methodologies (IRM) to privilege Aboriginal voices in knowledge construction and decision-making. This practice requires researchers to transition from safe and familiar research environments into unfamiliar and uncomfortable spaces.
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January 2025
Department of General Surgery, Instituto Mexicano del Seguro Social, Hospital General de Zona No. 33, Monterrey, MEX.
Extramammary Paget's disease (EMPD) is a rare cutaneous neoplasm characterized by the proliferation of malignant glandular-origin cells within the epidermis, occurring in areas other than the mammary areola. It is more prevalent in women (65%) than men (14%). Diagnosis can be confused with other neoplastic, inflammatory, or infectious conditions, often leading to initial inappropriate treatment with antifungals or topical steroids.
View Article and Find Full Text PDFInt J Biol Macromol
February 2025
Department of Public Health, School of Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:
As our understanding of Circular RNAs (circRNAs) continues to expand, accumulating evidence has demonstrated that circRNAs can interact with microRNAs and RNA-binding proteins to modulate gene expression. More importantly, a subset of circRNAs has been reported to possess coding potential, enabling them to translate into functional proteins. Recent studies also indicate that the N6-methyladenosine (mA)-modified start codon may function as an Internal Ribosome Entry Site (IRES), influencing the translation of circRNAs.
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