Pulmonary mucormycosis (PM) is a severe fungal infection that predominantly affects immunocompromised and diabetic individuals, and it is associated with a high mortality rate, particularly in cases of disseminated disease. We present the case of a 29-year-old liver transplant recipient who developed aggressive PM, confirmed through bronchoalveolar lavage. Treatment involved liposomal amphotericin B, followed by surgical debridement and right pneumonectomy. Despite these interventions, persistent infection required an Eloesser flap procedure for enhanced drainage. This case underscores the importance of early diagnosis and aggressive, multidisciplinary treatment approaches, including surgery and antifungal therapy, to improve outcomes in immunocompromised patients facing this life-threatening condition.
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http://dx.doi.org/10.7759/cureus.78649 | DOI Listing |
HCA Healthc J Med
February 2025
HCA Florida Northwest Hospital, Margate, Florida.
Background: Mucormycosis, commonly known as the "black fungus," is a severe infection affecting multiple organ systems, including the skin, brain, lungs, and gastrointestinal tract. This case report is focused on pulmonary mucormycosis, which is frequently observed in organ transplant recipients. Diagnostic challenges arise from nonspecific symptoms.
View Article and Find Full Text PDFCureus
February 2025
Cardiovascular and Thoracic Surgery, RUSH University Medical Center, Chicago, USA.
Pulmonary mucormycosis (PM) is a severe fungal infection that predominantly affects immunocompromised and diabetic individuals, and it is associated with a high mortality rate, particularly in cases of disseminated disease. We present the case of a 29-year-old liver transplant recipient who developed aggressive PM, confirmed through bronchoalveolar lavage. Treatment involved liposomal amphotericin B, followed by surgical debridement and right pneumonectomy.
View Article and Find Full Text PDFPediatr Transplant
May 2025
Department of Paediatric Gastroenterology, Hepatology and Nutrition, King's College Hospital, London, UK.
Background: Invasive fungal infections (IFI) remain a leading cause of mortality in liver transplant (LTX) patients with neutropenia. Hematopoietic growth factors and granulocyte transfusions (GTx) have been historically used in patients with neutropenia and after hematopoietic stem cell transplantation (HSCT) to treat IFI, but none thus far, in pediatric liver transplant recipients (PLTR).
Methods: We evaluated the safety and effect of GTx for life-threatening IFI, refractory to conventional antifungal treatment, in PLTR with hepatitis-associated aplastic anemia (HAAA) at King's College Hospital, London.
Zhonghua Jie He He Hu Xi Za Zhi
March 2025
Department of Respiratory and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang 550002, China.
COVID-19-associated invasive fungal infections are fungal infections that develop during COVID-19, including pulmonary aspergillosis (CAPA) and pulmonary mucormycosis (CAPM). This report presents a case of a patient with recurrent COVID-19 infections who showed pulmonary cavities and pleural effusion on chest CT. A mixed diagnosis of CAPA and CAPM was confirmed by histopathological analysis of bronchoalveolar lavage fluid and metagenomic next-generation sequencing.
View Article and Find Full Text PDFDiagn Microbiol Infect Dis
May 2025
Department of Critical Care Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China. Electronic address:
In this report, a 69-year-old man with fever, thrombocytopenia, and hepatic and renal dysfunction presented to our hospital. His disease progression was rapid, and he became unconscious. The patient was diagnosed with severe fever with thrombocytopenia syndrome (SFTS).
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