Spinal arteriovenous malformation (sAVM) is a rare vascular disease of the spine, presenting with symptoms of spinal cord involvement including sensory, motor, and autonomic symptoms. Early diagnosis is critical as the disease progresses to cause spinal cord compression, venous hypertension, and compression leading to spinal cord ischemia or infarction. In this case series, we present three cases treated at our institution over one year, with distinctly different anatomical sites of involvement. The three cases include two cases of type IV (perimedullary) AVMs - one at the C1-C2 level of the spinal cord and the other at the L1 level; and one case of type I (dural) AVM - at the D9-L1 level. Prompt diagnosis was made with the help of MRI and angiography. Endovascular embolization was performed for all patients, whose condition returned to normal within one year of follow-up.
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http://dx.doi.org/10.7759/cureus.78652 | DOI Listing |
Front Immunol
March 2025
Department of Orthopedics, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Background: Osteosarcoma, an aggressive bone malignancy predominantly affecting children and adolescents, presents significant therapeutic challenges with a 5-year survival rate below 30% in metastatic cases. T-cell exhaustion, characterized by the overexpression of immune checkpoint molecules, contributes to osteosarcoma progression and immune evasion. Although targeting these inhibitory pathways has shown potential in restoring T-cell activity, the molecular regulators of T-cell depletion in osteosarcoma are poorly understood.
View Article and Find Full Text PDFFront Neurol
February 2025
Department of Neurology, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.
Background: Varicella-zoster virus (VZV) central nervous system infection is typically observed in immunocompromised patients, and there is a lack of studies involving large samples of non-immunocompromised individuals. In this study, we retrospectively analyzed 108 non-immunocompromised patients diagnosed with VZV central nervous system infection.
Methods: This retrospective study was conducted in the Department of Neurology, Affiliated Nanjing Brain Hospital, Nanjing Medical University, China.
Front Cell Dev Biol
February 2025
Wayne State University, Detroit, MI, United States.
Fluids Barriers CNS
March 2025
School of Veterinary Medicine, University of Surrey, Guildford, GU2 7XH, UK.
Cerebrospinal fluid (CSF) plays a crucial role in maintaining brain homeostasis by facilitating the clearance of metabolic waste and regulating intracranial pressure. Dysregulation of CSF flow can lead to conditions like syringomyelia, and hydrocephalus. This review details the anatomy of CSF flow, examining its contribution to waste clearance within the brain and spinal cord.
View Article and Find Full Text PDFJ Neuroinflammation
March 2025
Neuroscience Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Spinal cord injury (SCI) can cause permanent dysfunction proceeding from multifaceted neuroinflammatory processes that contribute to damage and repair. Fidgetin-like 2 (FL2), a microtubule-severing enzyme that negatively regulates axon growth, microglial functions, and wound healing, has emerged as a potential therapeutic target for central nervous system injuries and neuroinflammation. To test the hypothesis that FL2 knockdown increases acute neuroinflammation and improves recovery after SCI, we examined the effects of nanoparticle-encapsulated FL2 siRNA treatment after a moderate contusion SCI in rats.
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