Background: Gastric cancer is the fifth most common cancer and the fourth leading cause of death worldwide. Most cases of newly diagnosed gastric cancer involve not only locally advanced tumor growth and regional lymph node metastases but also distant metastases. We report a rare case finding of a mass in the right inguinal area which is derived from gastric cancer.
Case Summary: A 68-year-old male initially diagnosed with an inguinal hernia presented with a 2 cm mass in the right inguinal area. Gastrointestinal symptoms led to the discovery of a stomach tumor. Biopsy confirmed gastrointestinal adenocarcinoma. The diagnosis was advanced gastric cancer with peritoneal dissemination, and the inguinal mass was due to direct infiltration. Due to gastrointestinal bleeding, the patient underwent palliative gastrectomy and lymph node dissection. Postoperatively, the patient received hyperthermic intraperitoneal chemotherapy and localized radiation therapy.
Conclusion: This case indicates that a systematic evaluation should be conducted during the initial consultation to explore the potential connection between unrecognized distant masses and the primary tumor.
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http://dx.doi.org/10.4240/wjgs.v17.i2.100244 | DOI Listing |
Background: Early diagnosis and intervention are essential for improving the prognosis and survival of gastric cancer (GC) patients. However, specific biomarkers for early GC diagnosis are still unavailable.
Methods: Data-independent acquisition (DIA) proteomics was employed to identify differentially expressed proteins (DEPs) between GC and adjacent non-tumor tissues.
Front Pharmacol
February 2025
Department of Geriatrics, Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, China.
Gastric cancer (GC) is a prevalent malignant tumor that originates from the epithelial cells of the gastric mucosa, predominantly in the form of adenocarcinoma. Extensive research has confirmed the significant role of autophagy in the initiation, progression, and chemoresistance of GC. The potential of traditional Chinese medicine (TCM) to exert anti-tumor effects by modulating autophagy has been demonstrated, particularly in the context of GC prevention and treatment.
View Article and Find Full Text PDFResearch (Wash D C)
March 2025
Department of General Surgery, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Exosomes (Exos) are emerging as noninvasive biomarkers for diagnosis and progression monitoring of gastric cancer (GC). However, the heterogeneity discrimination and ultrasensitive quantification of Exos presents a considerable analytical challenge, thereby impeding severely their clinical application. Herein, we propose an integrated terahertz metasensing platform for the discrimination of Exos in distinct subtypes of GC in a single step-through the simultaneous evaluation of the category and richness level of Exos membrane proteins.
View Article and Find Full Text PDFFront Oncol
February 2025
Department of Medical Oncology, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), and CIBERONC, Madrid, Spain.
Background: Immunotherapy has gained momentum with the discovery of novel antibodies targeting immunosuppressive proteins. HLA-E, a non-classical major histocompatibility complex class I (MHC-I) protein, exhibits immunosuppressive properties, potentially influencing tumor immune evasion mechanisms. The association between Human Leukocyte Antigen E (HLA-E) expression and outcomes in solid tumors remains unclear.
View Article and Find Full Text PDFInt J Gen Med
March 2025
Shenzhen Polytechnic University, Shenzhen, 518055, People's Republic of China.
Objective: To investigate immune cell crisis and excess histopathological features during the development and progression of infection in the gastric mucosa.
Methods: One thousand two hundred and seventy-six cases of infection were examined by endoscopic biopsy and endoscopic submucosal dissection (ESD) resection. The relationship between epithelial cells and immune cells and the pathological features of immune cell dysfunction and excess tissue were observed.
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