microRNAs (miRNAs), regulatory non-coding RNAs, can change translation, and decrease protein expression. miR-16 and miR-34a families are among the most abundant tumor suppressors and highly conserved microRNAs recognized. They have vital regulatory roles in health and disease. Their regulatory functions include biological processes such as improvement, differentiation, cell death, survival, and cell metabolism. The use of miR-16 and miR-34a families as biomarkers for cancer treatment is likely to improve patients with cancer. In this review, we update on recent advances in understanding the mechanism of miR-16 and miR-34 families function in cancer. Knowing about these mechanisms is effective for improving drugs and treatment methods. We also evaluated the reviewed studies and by introducing their weaknesses, we made suggestions for improving future research.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889592 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2025.e42733 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The role of miR-16 and miR-34a family in the regulation of cancers: A review.
Heliyon
February 2025
Department of Anatomical Sciences and Reproductive Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
microRNAs (miRNAs), regulatory non-coding RNAs, can change translation, and decrease protein expression. miR-16 and miR-34a families are among the most abundant tumor suppressors and highly conserved microRNAs recognized. They have vital regulatory roles in health and disease.
View Article and Find Full Text PDFMulti-target therapeutic modulation with natural compounds towards DNA repair MRN-checkpoint sensor genes (MRN-CSGs) and oncogenic miRNAs in breast cancer patients: a Clinico-Informatic study.
Integr Biol (Camb)
January 2024
Department of Biophysics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012India.
Breast cancer, more prevalent in women, often arises due to abnormalities in the MRN-checkpoint sensor genes (MRN-CSG), responsible for DNA damage detection and repair. Abnormality in this complex is due to the suppression of various effectors such as siRNAs, miRNAs, and transcriptional factors responsible for breast tumor progression. This study analyzed breast tumor samples (n = 60) and identified four common miRNAs (miR-1-3p, miR-210-3p, miR-16-5p, miR-34a-5p) out of 12, exploring their interactions with MRN-CSG.
View Article and Find Full Text PDFExpression profile of messenger and micro RNAs related to the histaminergic system in patients with five subtypes of breast cancer.
Front Oncol
August 2024
Department of Medical and Health Sciences, Collegium Medicum, WSB University, Dabrowa Górnicza, Poland.
Disparities in estrogen receptor (ER), progesterone receptor, human epidermal growth factor receptor 2 (HER2), and Ki67 proliferation indices facilitate the categorization of breast cancer into four principal subtypes: luminal A, luminal B, HER2-positive, and triple-negative breast cancer (TNBC). Preclinical studies investigating the therapeutic potential of histaminergic system targeting in breast cancer have shown promising results. This study aimed to assess the expression profiles of messenger ribonucleic acid (mRNA) and micro RNA (miRNA) related to the histaminergic system in five subtypes of breast cancer among Polish women.
View Article and Find Full Text PDFUnraveling the molecular pathogenesis of Type 2 Diabetes and its impact on female infertility: A bioinformatics and systems biology approach.
Comput Biol Med
September 2024
Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India. Electronic address:
Type 2 diabetes mellitus (T2D) has been linked with female infertility (FI). Nevertheless, our understanding of the molecular hallmarks and underlying mechanisms remains elusive. This research article aimed to find the hub genes, pathways, transcription factors, and miRNA involved.
View Article and Find Full Text PDFLong noncoding RNA profiling unveils LINC00960 as unfavorable prognostic biomarker promoting triple negative breast cancer progression.
Cell Death Discov
July 2024
Translational Oncology Research Center (TORC), Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), PO Box 34110, Doha, Qatar.
Long noncoding RNAs (lncRNAs) play a critical role in breast cancer pathogenesis, including Triple-Negative Breast Cancer (TNBC) subtype. Identifying the lncRNA expression patterns across different breast cancer subtypes could provide valuable insights into their potential utilization as disease biomarkers and therapeutic targets. In this study, we profiled lncRNA expression in 96 breast cancer cases, revealing significant differences compared to normal breast tissue.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!