Pulmonary sclerosing pneumocytoma (PSP) is a relatively rare benign lung tumor, and it is difficult to obtain an accurate diagnosis before surgery. Herein, we present a case of 34-year-old woman who came to our hospital for medical help due to cough and sputum for one month. She underwent a chest computed tomography (CT) scan which revealed a circular soft tissue density shadow in the upper lobe of the left lung. A needle biopsy was subsequently performed which revealed a probable lung carcinoid. To further evaluate the nature of the mass and determine a treatment plan, the patient subsequently underwent dual nuclide tracer including fluorine-18 labeled fluorodeoxyglucose (F-FDG) and gallium-68 labeled 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7,10-tetraaceticacid -D-Phel-Tyr3-Thr8-OC (Ga-DOTATATE) PET/CT imaging. The results showed that the lession presented increased both F-FDG and Ga-DOTATATE uptake, suggesting a neuroendocrine tumor. However, postoperative pathology confirmed that the lesion was PSP. Our case study suggests that PSP may presents varying degrees of increased F-FDG and Ga-DOTATATE uptake on positron emission tomography (PET)/CT imaging, which should be considered as one of the differential diagnoses for lung carcinoids.
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http://dx.doi.org/10.3389/fonc.2025.1511595 | DOI Listing |
Front Oncol
February 2025
Affiliated Hospital of Zunyi Medical University, Department of Nuclear Medicine, Zunyi, China.
Pulmonary sclerosing pneumocytoma (PSP) is a relatively rare benign lung tumor, and it is difficult to obtain an accurate diagnosis before surgery. Herein, we present a case of 34-year-old woman who came to our hospital for medical help due to cough and sputum for one month. She underwent a chest computed tomography (CT) scan which revealed a circular soft tissue density shadow in the upper lobe of the left lung.
View Article and Find Full Text PDFBreast Cancer Res Treat
February 2025
Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, 110029, India.
Purpose: Somatostatin receptor (SSTR) expression has been reported in estrogen receptor-positive (ER +) metastatic breast cancer (mBC) by pathology and immunohistochemistry studies. We aimed to investigate whether SSTR could be a viable target for PET imaging and potential theranostics in ER + mBC.
Methods: Thirty prospectively recruited patients with ER + mBC underwent PET/CT imaging with [F]FDG and [Ga]Ga-DOTATATE (within three weeks).
Eur J Nucl Med Mol Imaging
February 2025
Department of Medical Physics and Clinical Engineering, Oxford University Hospitals NHS FT, Oxford, UK.
Aim: To evaluate a deep learning-based time-of-flight (DLToF) model trained to enhance the image quality of non-ToF PET images for different tracers, reconstructed using BSREM algorithm, towards ToF images.
Methods: A 3D residual U-NET model was trained using 8 different tracers (FDG: 75% and non-FDG: 25%) from 11 sites from US, Europe and Asia. A total of 309 training and 33 validation datasets scanned on GE Discovery MI (DMI) ToF scanners were used for development of DLToF models of three strengths: low (L), medium (M) and high (H).
Eur J Nucl Med Mol Imaging
February 2025
Shanghai Institute of Medical Imaging, Shanghai, 200032, China.
Purpose: This study aims to develop and validate a deep learning framework designed to eliminate the second CT scan of dual-tracer total-body PET/CT imaging.
Methods: We retrospectively included three cohorts of 247 patients who underwent dual-tracer total-body PET/CT imaging on two separate days (time interval:1-11 days). Out of these, 167 underwent [Ga]Ga-DOTATATE/[F]FDG, 50 underwent [Ga]Ga-PSMA-11/[F]FDG, and 30 underwent [Ga]Ga-FAPI-04/[F]FDG.
World J Nucl Med
December 2024
Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Jerbai Wadia Road, Parel, Mumbai, India.
Patients of head and neck squamous cell carcinoma (HNSCC) experience increased risk of developing second primary cancer (SPC) necessitating active surveillance during their disease course. SPCs are associated with poor prognosis and are the leading cause of long-term morbidity and mortality impacting survival of patients with HNSCC. Small cell neuroendocrine carcinoma (SmNEC) is a rare but aggressive neoplasm with poor prognosis and high risk of local recurrence and distant metastasis.
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