This cross-sectional study aimed to investigate the corneal endothelial characteristics in elderly individuals with high myopia. We assessed corneal endothelial characteristics in 1065 eyes of 1065 elderly patients (549 highly myopic and 516 control eyes) using non-contact specular microscopy. Confirmation of suspected Fuchs endothelial corneal dystrophy (FECD) was performed with slit-lamp and confocal microscopy. Highly myopic eyes exhibited significantly greater central endothelial cell density (ECD) and coefficient of variation (CV) ( = 0.001 and = 0.002, respectively), and lower average cell area (AVG) and percent of hexagonality (HEX) ( = 0.014 and < 0.001, respectively) compared to control eyes. After adjusting for age and gender, axial length (AL) was positively correlated with ECD and CV ( = 0.130, < 0.001 and = 0.113, < 0.001, respectively), and was negatively correlated with AVG and HEX ( = - 0.105, = 0.001 and = - 0.204, < 0.001, respectively). FECD prevalence was 4.92% in highly myopic eyes and 3.29% in controls, with more advanced cases in highly myopic eyes ( = 0.036). In conclusion, longer AL was associated with increased corneal ECD, and greater endothelial pleomorphism and polymegethism in elderly patients. Highly myopic eyes appeared to have higher prevalence and severity of FECD. The study was registered on www.clinicaltrials.gov on February 26, 2017, with the registration number NCT03062085.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889312 | PMC |
http://dx.doi.org/10.1007/s43657-024-00186-6 | DOI Listing |
Cornea
March 2025
The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Purpose: To investigate the refractive predictability and corneal thickness change after femtosecond laser-assisted lenticule intrastromal keratoplasty (FS-LIKE) or small-incision lenticule intrastromal keratoplasty (SMI-LIKE).
Methods: Pentacam topography and optical coherence tomography measurements were taken of all eyes at 1 day and 1, 3, and 6 months after surgery. Anterior lamellar thickness, lenticule thickness, and posterior lamellar thickness were measured.
Purpose: To evaluate and compare non-corneal intraocular higher order aberrations (HOAs) in keratoconic and normal myopic eyes.
Methods: Eighty-eight keratoconic and 106 normal myopic eyes were examined using high-resolution (1) pyramidal ocular wavefront sensor PERAMIS (designed by CSO for SCHWIND eye-tech-solutions GmbH) and (2) anterior segment optical coherence tomography (AS-OCT) MS-39 (CSO). Intraocular HOAs were calculated by subtracting the total corneal aberrations measured by the AS-OCT from the total ocular aberrations measured by the pyramidal aberrometer.
Acta Ophthalmol
March 2025
Beijing Visual Science and Translational Eye Research Institute (BERI), Eye Center of Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China.
Purpose: To explore associations between stages of myopic macular degeneration (MMD) and visual acuity and influencing parameters.
Methods: Participants of the population-based study Beijing Eye Study (n = 3468 participants) underwent a detailed ocular and systemic examination.
Results: Assessable images were available for 3040 (87.
Acta Ophthalmol
March 2025
Department of Optometry and Vision, Faculty of Optics and Optometry, Universidad Complutense de Madrid, Madrid, Spain.
This meta-analysis investigates the effectiveness of outdoor activities in reducing the onset of myopia in children and adolescents by analysing changes in axial elongation and spherical equivalent refractive error. Following PRISMA guidelines and registered in PROSPERO (CRD42024592971), the study included randomized controlled trials (RCTs) and observational studies. The eligibility criteria targeted children and adolescents aged 6 to 18 years with varying levels of outdoor exposure.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
March 2025
Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China.
Purpose: To explore the characteristics of retinal, choroidal, and retrobulbar blood flows in myopic patients with posterior staphyloma (PS) using ultra-widefield optical coherence tomography angiography (UWF-OCTA) and Color Doppler imaging (CDI).
Methods: The retrospective cross-sectional study enrolled 134 adults with high myopia from the Eye and ENT Hospital of Fudan University from December 2021 to September 2022. After propensity score matching, 45 eyes of 30 patients and 45 eyes of 32 patients were included in the PS and non-PS (NPS) groups, respectively.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!