Antibacterial Activity, Antiadherence Activity, Antioxidant Activity, and Molecular Docking of Sweetbrair Rose () Extract on Periodontopathogens: and - An Study.

Introduction: extracts were prepared, and the antibacterial and anti-biofilm assays were investigated against two different periodontics-causing bacteria for the first time. The aim was to determine whether the extracts could restrict the growth of dental pathogens and to investigate the molecular docking between the ellagic acid of flower extracts and virulence proteins of dental pathogens.

Materials And Method: Antibacterial activity of various extracts was studied. Anti-adherence activity and molecular docking of the antibacterial components of the extract was analysed.

Result: The antibacterial activity of ethanol and methanol extracts of was determined using the standard agar well diffusion method. Among them, methanol extracts showed more activity against all the dental pathogens. Methanol extracts (300 μg/ml and 400 μg/ml) showed inhibitory zones of 13.6 ± 0.75 mm and 15.9 ± 0.57 mm against showed inhibitory zones of about 12.9 ± 0.57 mm and 16.6 ± 0.75 mm. Minimum inhibitory concentration studies revealed that 500 μg/ml of methanol extracts inhibited the turbid growth of in their broth tubes. Antiadherence test results showed that extracts significantly reduced the number of organisms adhering to the glass specimens against all the test cultures. The molecular docking report revealed a binding energy of about -3.57 Kcal/Mol between ellagic acid and mfa1 of . Ellagic acid and target protein cdtA of revealed a maximum binding energy of -4.33 Kcal/Mol.

Conclusion: The findings concluded that extracts can be a valuable additive in natural antidental biofilm products.