Introduction: MacrophagesHydrogen sulfide (H2 S), an endogenously produced gasotransmitter, is a wellknown inflammatory agent production successfully controlled with triphala in macrophages.
Materials And Method: The ELISA analysis revealed that triphala extracts suppress the protein expression of NFκB (p65) and downregulation of the CSE gene expression. Moreover, in the presence of propargylglycine (PAG) the expression of NFκB and CSE gene was further reduced.
Results: These results suggest that triphala could be a potent antiinflammatory effect that could be used for the treatment of many inflammatory disorders, including periimplantitis.
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http://dx.doi.org/10.4103/jpbs.jpbs_1059_24 | DOI Listing |
Br Poult Sci
March 2025
The National Institute of Poultry Husbandry, Harper Adams University, Newport, UK.
1. This study examined feeding practices that could affect the expression of intestinal calcium transporter gene, tibial mass, eggshell quality and production performance in 25-week-old Hy-Line Brown Laying Hens.2.
View Article and Find Full Text PDFEpilepsia
March 2025
Departamento de Neurologia e Neurocirurgia, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil.
The immune system is crucial for the correct brain development, and recent findings also point toward central control of immune response. As the immune system is not fully developed at birth, the early years become an important window for infections and for the development of epilepsy. Both central and even peripheral inflammation may impact brain function, promoting opening of the blood-brain/blood and cerebrospinal barriers and allowing entry of immune cells and cytokines, which in turn may affect neuron function and connections.
View Article and Find Full Text PDFJAMA Dermatol
March 2025
Service de Dermatologie et Allergologie, Faculté de Médecine, Sorbonne Université, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Paris, France.
Importance: VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is a monogenic disease caused by UBA1 somatic variants in hematopoietic progenitor cells, mostly involving adult men. It is associated with inflammatory-related symptoms, frequently involving the skin and hematological disorders. Recently described myelodysplasia cutis (MDS-cutis) is a cutaneous manifestation of myelodysplasia in which clonal myelodysplastic cells infiltrate the skin.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
March 2025
Department of Bioengineering, University of Texas at Dallas, Richardson, Texas, United States.
Purpose: After stromal injury to the cornea, the release of growth factors and pro-inflammatory cytokines promotes the activation of quiescent keratocytes into a migratory fibroblast and/or fibrotic myofibroblast phenotype. Persistence of the myofibroblast phenotype can lead to corneal fibrosis and scarring, which are leading causes of blindness worldwide. This study aims to establish comprehensive transcriptional profiles for cultured corneal keratocytes, fibroblasts, and myofibroblasts to gain insights into the mechanisms through which these phenotypic changes occur.
View Article and Find Full Text PDFJAMA Dermatol
March 2025
Department of Surgery, Arthur J.E. Child Comprehensive Cancer Centre, University of Calgary, Calgary, Alberta, Canada.
Importance: There is a need to identify the best performing risk prediction model for sentinel lymph node biopsy (SLNB) positivity in melanoma.
Objective: To comprehensively review the characteristics and discriminative performance of existing risk prediction models for SLNB positivity in melanoma.
Data Sources: Embase and MEDLINE were searched from inception to May 1, 2024, for English language articles.
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