Background: Oral cancer is the sixth most common cancer occurring anywhere in the globe. Cancers of the mouth are caused by tobacco and alcohol overuse, and also between pre-malignancy and full-fledged malignancy. In order to avoid the onset of illness, proper cleanliness of the mouth is important.
Objective: In this study we aimed to identify the potential inhibitor for Aurora kinase B as a potential therapeutic target for oral cancer from the phytocompounds from .
Methodology: Compounds from were screened against Aurora kinase B using a structure-based virtual screening approach using Pyrx software. Based on the scoring parameters best compounds were chosen to analysis the interaction by using Discovery studio visualizer.
Results: Four compounds-pedunculin, nevadensin, chrysoeriol, and genistein were selected as the most promising leads based on the scoring parameter.
Conclusion: These chemicals could be potential therapeutic candidates that need to be investigated further in the laboratory.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11888753 | PMC |
| http://dx.doi.org/10.4103/jpbs.jpbs_1251_24 | DOI Listing |
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