Background: Healthcare-associated infections (HAIs) caused by pathogens are a significant concern in tertiary hospitals worldwide, including those in Al-Kharj, Saudi Arabia. This study aimed to explore the bioactive compounds from and evaluate their antimicrobial activity against pathogens.
Materials And Methods: Methanolic extracts of the stem were prepared and subjected to phytochemical analysis, thin-layer chromatography (TLC), and antimicrobial testing using the well-diffusion method. The minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and cytotoxicity (MTT assay) were also evaluated.
Results: The extract contained several major phytochemicals with significant activity against pathogens. The MIC values were 50 mg/mL for , , and , 100 mg/mL for and , and 25 mg/mL for . The MBC values were 25 mg/mL for and 100 mg/mL for the other pathogens.
Conclusion: The methanolic extract of . demonstrated potent antimicrobial activity, with relatively low MIC and MBC values against pathogens responsible for HAIs.
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| http://dx.doi.org/10.4103/jpbs.jpbs_1253_24 | DOI Listing |
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