Aim: Assessment of mast cells density expression in oral premalignant and malignant lesions by histochemical analysis.
Materials And Methods: The study used a total of 120 tissue blocks that were formalin-fixed and paraffin-embedded. These blocks consisted of 40 cases of oral squamous cell carcinoma (OSCC), 40 cases of oral epithelial dysplasia, and 40 cases of normal oral mucosa (NOM).
Results: In the current investigation, a comparison was made between toluidine blue stained sections of normal oral mucosa, oral epithelial dysplasia and OSCC. The resultant value was determined to be statistically insignificant in all three categories, namely, oral epithelial dysplasia, oral squamous cell carcinoma (OSCC), and normal oral mucosa. The resultant values, calculated using an unpaired -test, were shown to be extremely significant ( = 0.001).
Conclusion: Research indicates that mast cells could be a significant marker for increased angiogenesis, which in turn could be used to predict carcinogenesis, its progression, and the prognosis of malignant lesions.
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| http://dx.doi.org/10.4103/jpbs.jpbs_920_24 | DOI Listing |
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