Aim: To evaluate the antifungal activity of Triple Antibiotic Paste (TAP) with Epigallocatechin Gallate (EGCG) against .
Materials And Methods: Disk diffusion test: Thirty Kirby-Bauer disks were soaked in: Group 1-TAP (ciprofloxacin, minocycline, and metronidazole in saline); Group 2-TAP + EGCG + saline; Group 3-EGCG + saline; Group 4-Fluconazole. Disks were dried, placed in a suspension, and incubated at 37°C for 24 hours. Zones of inhibition were measured.
Simulated Dentine Study: Forty single-rooted teeth were decoronated to 12 mm, cleaned and shaped with ProTaper files, and irrigated with saline. Canals were inoculated with , treated with medicaments after two days, and incubated for three days. After saline irrigation, sterile absorbent points were placed in Sabouraud Dextrose Agar for 48-hour incubation at 37°C. Colony-forming units (CFUs) were counted.
Results: Fluconazole produced the largest zones of inhibition, significantly larger than EGCG, EGCG + Fluconazole, and TAP + EGCG ( < 0.001).
Conclusion: is susceptible to EGCG, with Fluconazole exhibiting the greatest antifungal activity.
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| http://dx.doi.org/10.4103/jpbs.jpbs_1093_24 | DOI Listing |
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