Objectives: To assess the anticandidal efficacy of nine medicinal plants to drug resistant isolates from diabetic patients with chronic periodontitis. A comparison was done with chlorhexidine gluconate.
Methods: Isolates from the periodontal pockets of 121 diabetics with severe periodontitis was obtained. Sensitivity to four antifungal antibiotics was assessed by disc diffusion method. Anticandidal activity of cold ethanol and hot aqueous extracts of nine plants were evaluated by well diffusion method. Minimum inhibitory concentration (MIC) was determined by microtube broth dilution method.
Results: was found to be the predominant species. None of the isolates extended resistance to amphotericin B. Aqueous and ethanol extracts of extended notable anticandidal efficacy, and the ethanol extracts were more active. Chlorhexidine extended better efficacy than the plant extracts.
Conclusions: is the prevalent yeast among diabetics with periodontitis. Presence of multidrug resistant for is a challenge. and can be explored for the development of safer anticandidal agents.
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| http://dx.doi.org/10.4103/jpbs.jpbs_1143_24 | DOI Listing |
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