Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, manifests as a chronic, recurrent, and refractory intestinal inflammatory condition significantly impacting patients' quality of life. Despite ongoing research, its etiology and pathogenesis remain incompletely understood. Recent advancements in medical research highlight the critical role of drug combination therapies in managing IBD. This paper employs the strengths, weaknesses, opportunities, and threats framework to evaluate the four strategic elements (strengths, weaknesses, opportunities, and threats) pertaining to combination therapies for IBD. Among the strengths, the paper underscores the efficacy of multi-targeted strategies, the advancement of personalized medicine, and the mitigation of drug resistance. Nonetheless, the analysis identifies significant weaknesses, including the prohibitive cost of treatment, issues with patient compliance, and the necessity for comprehensive long-term safety data. The paper also delineates opportunities to augment therapeutic success through the incorporation of biomarkers, the application of artificial intelligence, and extensive international collaborative efforts. In contrast, the paper does not shy away from addressing the threats, which include the potential for therapeutic resistance and the logistical challenges inherent in global therapy deployment. These initiatives aim to refine future therapeutic practices, fostering safer, more effective, and personalized treatment paradigms for IBD patients.
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http://dx.doi.org/10.3748/wjg.v31.i9.100607 | DOI Listing |
Curr Opin Clin Nutr Metab Care
March 2025
Division of Human Nutrition and Health, Wageningen University & Research, Wageningen.
Purpose Of Review: Sarcopenia and frailty are common conditions, associated with worse clinical outcomes during critical illness. Recent studies on sarcopenia and frailty in ICU patients are presented in this review, aiming to identify accurate diagnostic tools, investigate the effects on clinical and functional outcomes, and propose possible effective interventions.
Recent Findings: The recent change of the sarcopenia definition underlines the importance of muscle strength over mass, this is however challenging to assess in ICU patients.
Cells
February 2025
Advanced Research Center for Geriatric and Gerontology, Akita University, Akita 010-8543, Japan.
Ageing is a major risk factor for cognitive and physical decline, but its mechanisms remain poorly understood. This study aimed to detect early cognitive and physical changes, and to analyze the pathway involved by monitoring two groups of mice: a young and an adult group. The study has identified the types of molecules involved in the hippocampus.
View Article and Find Full Text PDFOsong Public Health Res Perspect
March 2025
Division of International Affairs, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea.
Objectives: The study aimed to analyze the core capacities to implement World Health Organization International Health Regulations (IHR) in 6 countries: Indonesia, Cambodia, Vietnam, the Dominican Republic, Ghana, and the Republic of Korea.
Methods: Secondary data from relevant databases and reports, including the electronic State Party Self-Assessment Annual Reporting mechanism and global health security index, were used to assess health security in these countries. Descriptive statistics summarized the basic features of the scores, and a strengths, weaknesses, opportunities, and threats (SWOT) analysis was subsequently performed to identify factors affecting health security scores while highlighting key similarities and differences between countries.
Food Chem
March 2025
Departament de Nutrició, Ciències de l'Alimentació i Gastronomia, Universitat de Barcelona. Av Prat de La Riba, 171, 08921 Santa Coloma de Gramenet, Spain; Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), Universitat de Barcelona. Av Prat de La Riba, 171, 08921 Santa Coloma de Gramenet, Spain.
This study presents a pioneering comparison of target stable isotope ratios analysis and sesquiterpene (SH) fingerprinting for authenticating virgin olive oil (VOO) geographical origin. Both methods were selected for being among the most promising targeted and untargeted approaches, respectively. These methods were applied to the same sample set of nearly 400 VOO samples, covering diverse harvest years, cultivars and producers.
View Article and Find Full Text PDFHeliyon
February 2025
Spine Research Center of Wannan Medical College, Wuhu, China, 22, Wenchang West Road, China, Wuhu, 241001, China.
Background: Spondylolysis is commonly linked to low back pain in athletes, and the connection between muscle weakness and spondylolysis is unclear. Therefore, this study examined the biomechanics of spondylolysis and influence of muscle weakness by finite element (FE) analysis.
Methods: A patient's L1-S1 lumbosacral unit was scanned by computed tomography, and generated a three-dimensional pathology-free FE model.
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