In the contemporary medical landscape, the burgeoning interest in natural therapies, particularly for managing gastrointestinal disorders, has brought traditional Chinese medicine (TCM) to the forefront. This article explains the core principles and clinical applications of TCM in treating these conditions, furthering the discourse through an examination of integrated TCM strategies, as demonstrated in the study by Zhou . While TCM has shown promising clinical outcomes, it encounters significant hurdles in standardization, mechanistic research, and clinical validation. Future investigations should aim to solidify the scientific underpinnings of TCM and expand its use in gastrointestinal disease management, striving for a seamless fusion of traditional and contemporary medical practices.
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http://dx.doi.org/10.3748/wjg.v31.i9.103145 | DOI Listing |
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State Key Laboratory of Advanced Medical Materials and Devices, Medical College, Tianjin University, Tianjin, 300072, China.
Irreversible electroporation (IRE) is a minimally invasive, non-thermal tumor ablation technique that induces nanoscale membrane perforation, leading to immunogenic cell death (ICD). However, IRE alone is limited by uneven electric field attenuation, incomplete tumor ablation, and the immunosuppressive nature of the tumor microenvironment. To address these challenges, a multifunctional nanomaterial, vermiculite nanosheets/calcium peroxide nanosheets (VMT/CaO NSs), is developed to enhance the efficacy of IRE.
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College of Chemistry & Chemical Engineering, Qingdao University, Qingdao, 266071, China.
Biomolecule-engineered metal-organic frameworks (Bio-MOFs) are designed by incorporating biomolecules into or onto MOFs through covalent and non-covalent interactions. These composite frameworks exhibit unique catalytic and biological activities, making them highly suitable for various biocatalytic applications. In this review, we highlight recent advances in the material design, bioengineering methods, structural and functional regulation techniques, and biocatalytic applications of Bio-MOFs.
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March 2025
SAMRC Precision Oncology Research Unit (PORU), DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP) Pan African Research Institute (PACRI), University of Pretoria, Hartfield, Pretoria 0028, South Africa.
The peremptory need to circumvent challenges associated with poorly differentiated epithelial endometrial cancers (PDEECs), also known as Type II endometrial cancers (ECs), has prompted therapeutic interrogation of the prototypically intractable and most prevalent gynecological malignancy. PDEECs account for most endometrial cancer-related mortalities due to their aggressive nature, late-stage detection, and poor response to standard therapies. PDEECs are characterized by heterogeneous histopathological features and distinct molecular profiles, and they pose significant clinical challenges due to their propensity for rapid progression.
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