Background: Inflammation is a key factor contributing to aging-related morbidities. Inflammation is intimately linked to the iron metabolism in macrophages, and ferritin heavy chain (Fth) is the basis of iron metabolism in macrophages. Regulating Fth to control iron metabolism may help to reduce inflammation in macrophages, which can ultimately help to alleviate certain aging-related diseases.
Methods: The effects of total saponins from (TSPJs) in the intervention of aging-related obesity were explored. The and models were established using RAW264.7 macrophage cells and naturally aging rats and mice. The inflammation, iron content, and gene expressions of the models were analyzed. Senescence was induced in RAW264.7 cells with adriamycin (ADR), and Fth knockdown was introduced to the models to investigate related mechanisms.
Results: TSPJs reduced the iron content in the macrophages and prompted M2 polarization, which affected the JNK signaling pathway ( < 0.05) and reduced the expression of inflammatory cytokines in adipose tissue.
Conclusion: TSPJs mediate the iron metabolism of macrophages via Fth to reduce aging-related inflammation of the adipose tissue.
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| http://dx.doi.org/10.1016/j.jgr.2024.11.001 | DOI Listing |
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