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| http://dx.doi.org/10.3389/fspor.2025.1570340 | DOI Listing |
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A Novel Missense Variant of in Pulmonary Arterial Hypertension.
Circ Rep
March 2025
Department of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute Osaka Japan.
Background: Because Regnase-1, encoded by , suppresses the development of pulmonary arterial hypertension (PAH) by controlling pro-inflammatory cytokines, we aimed to identify variants in patients with PAH.
Methods And Results: We analyzed whole-genome sequence data of patients with PAH to search for disease-associated variants. The Regnase-1 p.
A rapid ecologic analysis, confirmed by a case-control study, identifies class I HLA alleles correlated to the risk of COVID-19.
J Transl Med
March 2025
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Bldg. Suite 333, 1900 North 12th Street, Philadelphia, PA, 19122, USA.
Background: Several studies suggest that the heterogeneous spread of SARS-CoV-2 pandemics started on December 2019 could be partially upheld by the prevalence of permissive class I HLA alleles in specific populations. Such HLA alleles are in fact unable to shape an efficient anti-viral immune-response in the hosts or sustain an exaggerated inflammatory T cell mediated response responsible for the COVID-19 disease. We previously reported an ecologic correlation between the risk of COVID-19 spreading across Italy and the germinal expression of permissive HLA-C*01 and -B*44 alleles in specific inter and intraregional populations along the first spreading wave.
View Article and Find Full Text PDFA nationwide comprehensive genomic profiling and molecular tumor board platform for patients with advanced cancer.
NPJ Precis Oncol
March 2025
Laboratory for Molecular Diagnostics, Jessa Hospital, Hasselt, Belgium.
The Belgian Approach for Local Laboratory Extensive Tumor Testing (BALLETT) study assessed the feasibility of using comprehensive genomic profiling (CGP) in clinical decision-making for patients with advanced cancers. This multi-center study enrolled 872 patients from 12 Belgian hospitals. CGP was performed on tumor tissues using a standardized CGP panel (523 genes) across nine laboratories with success in 93% of patients and a median turnaround time of 29 days.
View Article and Find Full Text PDFSynthesis and antitumor evaluation of amino acid conjugates of monocarbonyl curcumin in hepatocellular carcinoma cell.
Sci Rep
March 2025
College of Public Health, Anhui University of Science and Technology, Hefei, 230000, China.
Curcumin possesses a variety of pharmacological properties, particularly anticancer activity. However, its clinical utility is limited by its poor water solubility and low bioavailability. To alleviate the problems, our previous research demonstrated that mono-carbonyl curcumin easters can be employed for the development of novel anticancer agents.
View Article and Find Full Text PDFSystematic review of applied transportability and generalizability analyses: A landscape analysis.
Ann Epidemiol
March 2025
Core Clinical Sciences, 401-34 W. 7(th) Ave., Vancouver, BC, V5Y 1L6 Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8 Canada. Electronic address:
Transportability and generalizability analysis are novel causal inference methods that quantitatively assess external validity. Currently, it is unclear how these analyses are applied in practice. To characterize applications and methods, we conducted a landscape analysis of applied transportability and generalizability analyses using a systematic literature search of PubMed, CINAHL and Embase supplemented with hand-searches.
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