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| http://dx.doi.org/10.1016/j.jscai.2024.102430 | DOI Listing |
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Purpose: The proximal femur is a frequent site of cancer dissemination in the extremities. Patients treated surgically for skeletal metastases have poorer overall health compared to other orthopedic patients, with only one-third expected to survive two years post-surgery. Choosing a treatment that minimizes revision risk and ensures the implant outlives the patient is therefore crucial.
View Article and Find Full Text PDFThe Paediatric European Confederation of Medical Mycology (ECMM) Quality (Paed-EQUAL) Candida Score for the Management of Candidaemia in Children and Neonates.
Mycoses
March 2025
Department I of Internal Medicine, European Diamond Excellence Centre for Medical Mycology (ECMM), and Centre for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf (ABCD), Cologne, Germany.
Candidaemia in children is associated with high mortality. The epidemiology of Candida bloodstream infection is changing with rising rates of fluconazole resistance worldwide and the emergence of novel multidrug-resistant species such as Candida auris, which is associated with outbreaks. Guidelines on the management of candidaemia emphasise identification of species and determination of antifungal susceptibility to guide appropriate treatment, performing relevant investigations to rule out deep-seated infection, and removal of central venous catheters.
View Article and Find Full Text PDFArtificial Intelligence and Machine Learning: An Updated Systematic Review of Their Role in Obstetrics and Midwifery.
Cureus
March 2025
Department of Midwifery, Faculty of Health and Caring Sciences, University of West Attica, Athens, GRC.
Artificial intelligence (AI) and machine learning (ML) are rapidly evolving technologies with significant implications in obstetrics and midwifery. This systematic review aims to evaluate the latest advancements in AI and ML applications in obstetrics and midwifery. A search was conducted in three electronic databases (PubMed, Scopus, and Web of Science) for studies published between January 1, 2022, and February 20, 2025, using keywords related to AI, ML, obstetrics, and midwifery.
View Article and Find Full Text PDFPre-clinical Safety Study of Cold Atmospheric Plasma (CAP) Produced by an Inbuilt CAP Device and ROS Mediated Apoptotic Activity in Human Skin Melanoma Cells.
Curr Pharm Des
March 2025
Pharmacology and Drug Discovery Research Laboratory, Division of Life Sciences; Institute of Advanced Study in Science and Technology (IASST), Vigyan Path, Guwahati, PIN-781035 Assam, India.
Introduction: In recent decades, Cold Atmospheric Plasma (CAP) has become increasingly popular in healthcare for managing diseases, especially skin cancer. This study aimed to assess the preclinical safety of an indigenously developed dielectric barrier discharge-CAP device and its cytotoxic efficacy against melanoma cells while adhering to OECD 402 guidelines for acute dermal toxicity study. The safety evaluation includes ex vivo studies on mouse peritoneal exudates and in vivo acute dermal toxicity tests on Wistar rats.
View Article and Find Full Text PDF[Adherence to the national guidelines regarding referral of patients with knee osteoarthritis to orthopedic consultation].
Lakartidningen
March 2025
docent, överläkare, ortopedi, Hässleholms sjukhus; Göte-borgs universitet; Lunds universitet.
The aim of the study was to investigate: 1) the proportion of referrals from primary care to orthopedic consultations that included the information requested by the national guidelines for patients with knee osteoarthritis, and 2) the proportion of referrals that specified whether patients had completed first-line treatment. A total of 140 referrals were examined. None of the referrals adhered fully to the national guidelines, and none included information on whether the patient had completed first-line treatment.
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