Calcineurin inhibitor-induced pain syndrome (CIPS) is a rare but serious condition characterized by severe lower leg pain, often associated with elevated tacrolimus (TAC) levels. We report the case of a 57-year-old woman with rheumatoid arthritis (RA) who developed CIPS following a drug interaction between TAC and clarithromycin (CAM), a common macrolide antibiotic. Discontinuation of TAC led to a rapid resolution of symptoms. This case highlights the importance of monitoring TAC levels and being cautious of drug interactions, especially in primary care settings, to prevent adverse events like CIPS.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890048 | PMC |
| http://dx.doi.org/10.1002/jgf2.769 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Opioid withdrawal syndrome induced by naldemedine administration in a cancer patient without brain metastasis.
Palliat Support Care
March 2025
Departments of Psycho-oncology, Saitama Medical University International Medical Center, Saitama, Japan.
Objectives: Naldemedine is a peripherally acting μ-opioid receptor antagonist used to treat opioid-induced constipation. As this drug does not cross the blood-brain barrier, it is believed that patients without brain metastases do not experience opioid withdrawal symptoms.
Methods: Here, we experienced a case in which a cancer patient without brain metastasis presented with anxiety and restlessness that was severe enough to interfere with daily life.
Gallbladder perforation due to the obstructing periampullary duodenal diverticulum (Lemmel's syndrome): a case report.
J Surg Case Rep
March 2025
Department of Gastrointestinal Surgery, Birat Medical College and Teaching Hospital (BMCTH), Tankisinwari, Morang, Biratnagar 56613, Nepal.
Lemmel's syndrome is a rare condition characterized by obstructive jaundice due to the periampullary duodenal diverticulum in the absence of choledocholithiasis or tumors. Its infrequent occurrence and non-specific clinical presentation can make it difficult to distinguish from other conditions. We present a case of Lemmel's syndrome in a 63-year-old male who exhibited symptoms of abdominal pain in right hypochondrium, vomiting, and fever.
View Article and Find Full Text PDFEffectiveness of Electromagnetic Field Therapy in Mechanical Low Back Pain: A Randomized Controlled Trial.
J Pain Res
March 2025
Program of Physical Therapy, Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, 61421, Saudi Arabia.
Background: Between half and three quarters of the working-age population in today's industrialized globe suffers from lower back pain. The presence of a myofascial trigger point-a hyperirritable painful area comprised of a small number of muscle fibers-identifies mechanical back pain sufferers as suffering from myofascial pain syndrome, a chronic pain disorder. This research objectives to determine whether mechanical back pain patients' pain severity and functional disabilities are influenced by electromagnetic field therapy.
View Article and Find Full Text PDFThe characteristics of brain function alterations in patients with chronic prostatitis/chronic pelvic pain syndrome across varying symptom severities evaluated by NIH-CPSI.
Front Neurosci
February 2025
Department of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent condition in urology characterized by chronic pain. The pathogenesis of CP/CPPS remains unclear.
Methods: We enrolled 45 eligible CP/CPPS patients and 45 healthy volunteers.
An online survey among convalescents 5 months post SARS-CoV-2 infection in China.
Biosaf Health
August 2024
NHC Key Laboratory of Biosafety, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China.
The effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection persist months and years after recovery. We conducted an online survey to assess the health condition of convalescents approximately 5 months following the primary infection of SARS-CoV-2. The study recruited 5,510 individuals who were primary infected, 626 participants who had experienced reinfection, and 521 participants who were without infective history.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!