Purpose: Polycystic Ovary Syndrome (PCOS) is one of the most common gynecological endocrine conditions, affecting both the physical and mental health, and the quality of life of women. PCOS was associated with diverse mental disorders but studies in Korean populations were limited. This study aims to investigate the risk of mental disorders in PCOS patients in Korea.
Patients And Methods: We evaluated the risk of five mental disorders in PCOS patients using health insurance billing data from the National Health Insurance Corporation. We selected 188,973 PCOS patients and 412,022 control individuals. Prevalence, cumulative incidence, and Hazard ratios (HR) were calculated for each mental disorder.
Results: We found PCOS patients to have increased prevalence of depressive disorders (Odds ratios (OR) 1.208[1.185-1.232]), bipolar disorders (OR 1.403[1.330-1.479]), and anxiety disorders (OR 1.089[1.064-1.114]); however, PCOS patients also had lower prevalence of schizophrenia (OR 0.686[0.638-0.737]) and sleep disorder (OR 0.911[0.888-0.935]). The PCOS patients exhibited a significantly greater HR in depressive disorder (adjusted HR 1.244[1.148-1.347]), bipolar disorder (adjusted HR 1.502[1.139-1.981]), anxiety disorder (adjusted HR 1.147[1.050-1.252]), and sleep disorder (adjusted HR 1.228[1.112-1.356]).
Conclusion: Our results suggest that PCOS patients have increased risk of depressive disorders, bipolar disorders, anxiety disorders, and sleep disorders. This study supports international PCOS guidelines that recommend screening for mental health disorders.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890313 | PMC |
| http://dx.doi.org/10.2147/IJWH.S490673 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: In vitro oocyte maturation (IVM) is not a novel concept; however, its wide-scale practice has been limited because of the lower clinical outcomes compared to conventional assisted reproductive technologies.
Methods: This comprehensive review addresses the significant advances made in oocyte in vitro maturation with the biphasic capacitation (CAPA)-IVM strategy applied to small ovarian antral follicles in humans over the last 10 years. CAPA-IVM consists of a prematuration phase wherein immature oocytes are temporarily meiotically arrested to gain competence before undergoing meiotic resumption.
Enhancing understanding of endometrial function in patients with PCOS: clinical and immunological insights.
J Ovarian Res
March 2025
Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Objective: To evaluate the pregnancy and perinatal outcomes of different phenotypes of polycystic ovary syndrome (PCOS) patients during the frozen embryo transfer (FET) cycles. Additionally, to analyze the T cell balance in the endometrium of PCOS patients and explore its relationship with various PCOS phenotypes.
Design: Retrospective cohort study.
The significant role of IL-15, IL-22, IL-37, and caspase 9 in polycystic ovary syndrome: A case-control study in a sample of Iraqi women.
J Genet Eng Biotechnol
March 2025
Department of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Bisha, Bisha, 61922 P.O. Box 551, Saudi Arabia; Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, University of Elmam El Mahdi, Kosti, 209 P.O. Box 27711, Sudan.
The study aims to evaluate the significant role of interleukin 15 (IL-15), IL-22, IL-37, and Caspase 9 gene expression in polycystic ovary syndrome (PCOS), focusing on the underlying mechanisms and potential diagnostic or therapeutic implications. Peripheral blood has been collected, and serum was separated for the evaluation of the serum IL-15, IL-22, and IL-37. The ELISA technique has been carried out to determine the serum levels of understudied factors mentioned above in Iraqi women patients diagnosed with PCOS (No.
View Article and Find Full Text PDFIn vitro maturation of oocytes (IVM): historical landmarks, current status and future perspectives.
Syst Biol Reprod Med
December 2025
Laboratory of Histology and Embryology, Aristotle University Medical School, Thessaloniki, Greece.
One of the major advancements in fertilization (IVF) has been the development of culture media that enhance gamete maturation and sustain embryo development up to the blastocyst stage. The deep understanding of the mechanisms involved in gametogenesis and the complex sequence of events surrounding nuclear and cytoplasmic maturation has also enabled the development of efficient maturation (IVM) protocols. This review outlines the major landmarks in the history of maturation of oocytes, the advantages and importance of its clinical application in human, especially in patients with Polycystic Ovary Syndrome (PCOS), Resistant Ovary Syndrome, high antral follicle count or oncology patients, as well as the safety and efficacy of the technique.
View Article and Find Full Text PDFUsing non-invasive indicators to screen the PCOS population for liver disease - a single-centre study.
Endokrynol Pol
March 2025
Department of Internal, Autoimmune and Metabolic Diseases, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
Introduction: Studies show an association between polycystic ovary syndrome (PCOS) and an increased incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) in this patient group. Diagnostic tools that can screen relevant groups of PCOS' patients for liver disease are still being sought.
Material And Methods: Our study included 242 patients with PCOS diagnosed on the basis of the Rotterdam criteria, which we divided according to phenotypes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!