Background: Changes in retinal and choroidal structures are key biomarkers for predicting, diagnosing, and monitoring various ocular conditions, including myopia.
Objective: To assess the characteristics of the retinal and choroidal thicknesses in myopic young adult males using swept-source optical coherence tomography (SSOCT).
Methods: This cross-sectional comparative study included 198 young adults with a mean age of 21.87 ± 1.69 years, only male subjects were recruited for this study, comprising 102 diagnosed with myopia and 96 with emmetropia. Refraction was assessed using an autorefractometer, and comprehensive SSOCT scans were conducted to measure the thickness of the retina and choroid at nine predefined locations. Data analysis focused on identifying significant patterns and correlations between myopia and retinal and choroidal thickness.
Results: Myopic subjects with a mean of -2.66 ± 1.59D exhibited significantly decreased retinal thickness compared to emmetropic with a mean of 0.18 ± 0.39D, ( < 0.01). Similarly, their choroidal thickness was also significantly thinner ( < 0.01). The findings showed a weak but statistically significant inverse correlation between retinal thickness and the spherical equivalent of myopia (r = -0.257, < 0.01). Correspondingly, a stronger inverse correlation was observed between choroidal thickness and the spherical equivalent of myopia (r = -0.306, < 0.01). Choroidal thickness in all studied areas showed an inverse correlation with the degree of myopia ( < 0.05), except in the superior outer region, where the association was not statistically significant ( = 0.056).
Conclusion: The study identified significant differences in the retinal and choroidal structures between myopic and emmetropic individuals. The use of SSOCT effectively detected these morphological changes in myopic young adults, offering valuable insights into myopia's pathophysiology and potentially guiding targeted therapeutic strategies for myopia control.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890031 | PMC |
| http://dx.doi.org/10.7717/peerj.19030 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Quantitative Evaluation of Changes in Retinal and Choroidal Blood Flow Following Strabismus Surgery.
Transl Vis Sci Technol
March 2025
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Purpose: This study aimed to investigate the effects of extraocular muscle recession performed as part of strabismus surgery on posterior retinal and choroidal blood flow.
Methods: A single-center prospective study was conducted on patients who underwent strabismus surgery. Optical coherence tomography, optical coherence tomography angiography, and laser speckle flowgraphy of the macula were performed before surgery and at one week, one month, and four months after surgery.
Fractal Dimension Analysis of Peripapillary Microvasculature in Primary Congenital Glaucoma.
J Glaucoma
March 2025
Department of Ophthalmology, Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR.
Precis: In this prospective multicenter study, eyes with primary congenital glaucoma exhibited lower retinal vascular parameters compared to healthy controls, as assessed by optical coherence tomography angiography fractal dimension analysis.
Purpose: To study the retino-choroidal peripapillary microvascular pattern in primary congenital glaucoma (PCG) using fractal dimension (FD) analysis and compare it to healthy controls.
Methods: This was a prospective multicenter comparative study.
Choroidal thickness as predictor of subclinical carotid atherosclerosis in adults with type 1 diabetes.
Sci Rep
March 2025
Department of Endocrinology & Nutrition, Hospital de la Santa Creu i Sant Pau, Sant Quintí, 89, 08041, Barcelona, Spain.
Patients with Type 1 Diabetes (T1DM) have a higher risk of cardiovascular disease. This study used carotid ultrasound to identify subclinical carotid plaques and Optical Coherence Tomography (OCT) to evaluate ophthalmological markers as predictors of carotid plaque presence in 242 adults with T1DM, employing machine learning models for early risk assessment. Individuals with carotid plaques (N = 67) did not show significant differences in retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) and inner plexiform layer (IPL) complex compared to those without (N = 175).
View Article and Find Full Text PDFPeripapillary alterations in Idiopathic Normal Pressure Hydrocephalus.
Retina
March 2025
Ophthalmology Unit, DIMEC, Alma Mater Studiorum University of Bologna, Italy.
Purpose: To evaluate the peripapillary area in eyes of patients with Idiopathic Normal Pressure Hydrocephalus (iNPH) before and after shunt surgery.
Methods: Twenty iNPH patients were prospectively recruited. Enhance depth imaging-optical coherence tomography (EDI-OCT) was performed to image the peripapillary region.
Outcomes of Persistent Exudative Retinal Detachments Following Proton Beam Irradiation for Choroidal Melanoma.
Retina
March 2025
Ocular Melanoma Center, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114.
Purpose: To assess the outcomes of persistent large exudative retinal detachments (ERD) following proton beam irradiation (PBI) for choroidal melanoma.
Methods: A retrospective study evaluated patients with a diagnosis of ERD in the setting of choroidal melanoma treated with PBI at a single academic tertiary center. Inclusion criteria were the presence of an ERD for at least 3 clock hours at the time of melanoma diagnosis.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!