Pregnancy-induced changes to spinal anatomy and physiology can increase the complexity of neurosurgical intervention in this population. There are numerous reports focused on the neurosurgical management of intracranial pathology for pregnant patients. However, less is known about the neurosurgical management of acute spinal pathology. This study aims to discuss the management of emergent spinal pathology during late-term pregnancy. This is a case series of acute spinal pathologies in pregnancy. Epidural spinal needle fracture, epidural abscess, disc herniation causing an acute neurological deficit, and potential spine trauma. An extensive literature search relevant to the operative cases was performed to highlight the relevant themes to management. (1) The epidural spinal needle fracture was managed by surgical exploration under local anesthesia. (2) The epidural abscess was managed with laminectomy and surgical evacuation of the infective mass under general anesthesia. (3) The acute disc herniation was managed with laminectomy and discectomy under general anesthesia. All three examples were managed with emergent surgeries with improvement of symptoms. (4) The potential spine trauma was managed nonoperatively. Relevant similar cases from the literature review were summarized and strategies for management were outlined. Several factors such as anesthesia type, positioning, and operation sequencing must be considered when managing acute spinal pathology in late-term pregnant patients, necessitating multi-disciplinary input. However, effective management can result in successful surgical intervention and improvement of symptoms.
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http://dx.doi.org/10.4103/jcvjs.jcvjs_24_24 | DOI Listing |
Cureus
February 2025
Department of Spine Surgery, Kameda Medical Center, Chiba, JPN.
Various conditions can cause myelopathy due to cervical epidural fluid collection, including idiopathic cervical epidural hematoma, traumatic cervical epidural hematoma, infectious myelitis, epidural abscess, spinal cord infarction, post-traumatic cerebrospinal fluid (CSF) leakage, and epidural tumors. While physical compression from hematoma, abscess, or epidural tumors is common, and carcinomatous meningitis can cause CSF flow obstruction and accumulation leading to myelopathy, rapid progression of serous fluid collection causing myelopathy is rare. We report a case of myelopathy caused by rapid accumulation of epidural exudate from a metastatic tumor in the cervical lamina.
View Article and Find Full Text PDFBMC Musculoskelet Disord
March 2025
Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Background: Spontaneous psoas hematoma is a very rare clinical entity, and the pathogenesis and pathologic mechanisms of spontaneous psoas hematoma remain unclear, thus, it is of great value to explore.
Case Presentation: We encountered a patient who developed femoral nerve paralysis due to psoas muscle hematoma following posterior lumbar fusion surgery. A 69-year-old female with lumbar spinal canal stenosis underwent posterior lumbar fusion at the L3-4 and L4-5 levels.
Eur J Orthop Surg Traumatol
March 2025
Second People Hospital of Hunan, Changsha, China.
Purpose: To evaluate the clinical efficacy of ultrasound-guided local anesthetic injection combined with myofascial trigger point mini-needle knife therapy for acute lumbar sprain management.
Methods: In this prospective study, 60 patients (January-July 2024) received ultrasound-guided injections at the third lumbar (L3) transverse process attachment and posterior medial spinal nerve branch, combined with miniscalpel-needle release of MTrPs. Visual analog scale (VAS), modified Oswestry disability index (MODI), and lumbar range of motion (ROM) were assessed pre-treatment and on days 3 and 7 post-treatment.
J Neurochem
March 2025
Koç University Research Center for Translational Medicine (KUTTAM), Koç University, İstanbul, Türkiye.
Central nervous system (CNS) pericytes play crucial roles in vascular development and blood-brain barrier maturation during prenatal development, as well as in regulating cerebral blood flow in adults. They have also been implicated in the pathogenesis of numerous neurological disorders. However, the behavior of pericytes in the adult brain after injury remains poorly understood, partly due to limitations in existing pericyte ablation models.
View Article and Find Full Text PDFJ Neuroinflammation
March 2025
Neuroscience Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Spinal cord injury (SCI) can cause permanent dysfunction proceeding from multifaceted neuroinflammatory processes that contribute to damage and repair. Fidgetin-like 2 (FL2), a microtubule-severing enzyme that negatively regulates axon growth, microglial functions, and wound healing, has emerged as a potential therapeutic target for central nervous system injuries and neuroinflammation. To test the hypothesis that FL2 knockdown increases acute neuroinflammation and improves recovery after SCI, we examined the effects of nanoparticle-encapsulated FL2 siRNA treatment after a moderate contusion SCI in rats.
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