Breast augmentation is a popular cosmetic procedure that is generally considered safe. However, the rising trend of nonspecialists performing these procedures has increased the risk of complications, including rare but serious acute bleeding. We present a case of a healthy 22-year-old patient who experienced acute bleeding after bilateral breast augmentation by a nonplastic surgeon, resulting in massive hypovolemic shock that required 27 packed red blood cell (PRBC) transfusions and led to acute cardiopulmonary failure. The patient had 2 cardiac arrests, necessitating resuscitation and extracorporeal membrane oxygenation, which was removed after 6 days. An emergency surgical revision was performed to remove the breast implants for effective hemostasis. This case highlights the significant risks associated with cosmetic breast procedures and emphasizes the importance of early surgical intervention in cases of acute bleeding. Patients should be made aware of these risks, and cosmetic surgery should only be performed by trained specialists.
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http://dx.doi.org/10.1097/GOX.0000000000006592 | DOI Listing |
Brief Bioinform
March 2025
Department of Genetics and Biochemistry, Clemson University, Clemson, SC 29634, United States.
Breast cancer remains a significant global health challenge due to its complexity, which arises from multiple genetic and epigenetic mutations that originate in normal breast tissue. Traditional machine learning models often fall short in addressing the intricate gene interactions that complicate drug design and treatment strategies. In contrast, our study introduces GEMDiff, a novel computational workflow leveraging a diffusion model to bridge the gene expression states between normal and tumor conditions.
View Article and Find Full Text PDFNat Commun
March 2025
Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Overcoming immunosuppression in the tumor microenvironment (TME) is crucial for developing novel cancer immunotherapies. Here, we report that IL-16 administration enhances the polarization of T helper 1 (Th1) cells by inhibiting glutamine catabolism through the downregulation of glutaminase in CD4 T cells and increases the production of Th1 effector cytokine IFN-γ, thus improving anti-tumor immune responses. Moreover, we find that establishing an IL-16-dependent, Th1-dominant TME relies on mast cell-produced histamine and results in the increased expression of the CXCR3 ligands in tumor-associated macrophages (TAM), thereby improving the therapeutic effectiveness of immune checkpoint blockade (ICB).
View Article and Find Full Text PDFPlast Reconstr Surg Glob Open
March 2025
From the Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Basel, Switzerland.
Breast augmentation is a popular cosmetic procedure that is generally considered safe. However, the rising trend of nonspecialists performing these procedures has increased the risk of complications, including rare but serious acute bleeding. We present a case of a healthy 22-year-old patient who experienced acute bleeding after bilateral breast augmentation by a nonplastic surgeon, resulting in massive hypovolemic shock that required 27 packed red blood cell (PRBC) transfusions and led to acute cardiopulmonary failure.
View Article and Find Full Text PDFJPRAS Open
March 2025
University of Milan, Reconstructive and Aesthetic Plastic Surgery School - Clinica San Carlo - Plastic Surgery Unit - Via Ospedale 21, 20037 Paderno Dugnano Mi (Milan), Italy.
Classical mastopexy techniques have always been adopted to treat breast ptosis of all grades; however, they only lift the breast without addressing upper pole fullness and firmness. An increasing number of patients are seeking different aesthetic outcomes in terms of shape and pertness, comparable to those of augmentation mammaplasty without breast volume increase. To address this request, we propose an innovative surgical approach, iso-volumetric implant shape (IVIS) mastopexy.
View Article and Find Full Text PDFBiomaterials
March 2025
Department of Chemistry, Korea University, Seoul 02841, Korea. Electronic address:
Small molecule-based multifunctional optical diagnostic materials have garnered considerable interest due to their highly customizable structures, tunable excited-state properties, and remarkable biocompatibility. We herein report the synthesis of a multifaceted photosensitizer, PPQ-CTPA, which exhibits exceptional efficacy in generating Type I reactive oxygen species (ROS) and thermal energy under near-infrared-II (NIR-II, >1000 nm) laser excitation at 1064 nm, thereby combining photodynamic therapy (PDT) and photothermal therapy (PTT) functionalities. To enhance therapeutic efficacy, we engineered lonidamine (LND) by conjugating it with triphenylphosphonium (TPP) cations, producing LND-TPP.
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