Background: Ensuring uninterrupted HIV treatment for female sex workers (FSWs), who face a disproportionately high HIV burden, is crucial for curbing HIV transmission and disease. Structural, social, and legal barriers impede their access to HIV services. The differentiated service delivery (DSD) model, designed to tailor and decentralise HIV services, aims to overcome these barriers. However, the impact of the DSD model for HIV treatment uptake among FSWs in sub-Saharan Africa (SSA) is not well documented.
Objectives: To assess the implementation of the DSD model in improving HIV treatment outcomes among FSWs in SSA.
Method: A systematic review literature was conducted to include available records from January 2019 to March 2024, using electronic databases such as EBSCOhost, Science Direct, SCOPUS, PubMed Central, and others. Ten studies met the eligibility criteria for inclusion for the review. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and was registered with the International Prospective Register of Systematic Reviews (ID: CRD42023440551).
Results: The uptake of HIV treatment services varied depending on whether the DSD model was facility-based, community-based, or a combination of both. Community-based models were generally preferred and led to better treatment outcomes due to their comprehensive health services.
Conclusion: To improve HIV treatment outcomes for FSWs in SSA, it is essential to strengthen DSD model implementation, access, and utilisation, particularly at the community level.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886544 | PMC |
http://dx.doi.org/10.4102/sajhivmed.v26i1.1626 | DOI Listing |
J Virol
March 2025
Institute of Clinical Medicine, National Yang Ming Chiao Tung University-Yangming Campus, Taipei, Taiwan.
Unlabelled: HIV-1 protease (PR) activation is triggered by Gag-Pol dimerization. We previously reported that reverse transcriptase (RT) amino acid substitution mutations resulted in p66/51RT heterodimer instability associated with impaired PR activation, and that treatment with (, an RT dimerization enhancer) increased PR activation, suggesting RT involvement. However, the contribution of RT to PR activation via the promotion of Gag-Pol dimerization has not been corroborated.
View Article and Find Full Text PDFEur J Immunol
March 2025
Department of Experimental Immunology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
Young females are at high risk of acquiring HIV-1 infections and an imbalance in the vaginal microbiome enhances susceptibility to HIV-1 infection. More insights into the underlying mechanisms could open up new strategies to prevent HIV-1 acquisition and dissemination. Here, we investigated the effect of anaerobic bacteria associated with bacterial vaginosis (BV) on HIV-1 transmission by two distinct dendritic cell (DC) subsets, that is, inflammatory monocyte-derived DCs (moDCs) and primary CD1c DCs.
View Article and Find Full Text PDFCampbell Syst Rev
March 2025
Liverpool School of Tropical Medicine, International Public Health Liverpool UK.
This is the protocol for a Campbell systematic review. The objectives are as follows. The primary objective of this systematic review is to evaluate and synthesise both published and unpublished literature on the effectiveness of sexual and reproductive health blended learning approaches for capacity strengthening of healthcare practitioners in LMICs.
View Article and Find Full Text PDFMed Trop Sante Int
December 2024
Service de médecine interne, CHU de Libreville, BP 2228, Libreville, Gabon.
Background: HIV/AIDS infection is endemic in sub-Saharan Africa. It is manifested by a variety of opportunistic diseases that usually occur when the CD4 count is below 200/mm, but also during the immune restoration syndrome (IRS) that occurs under highly active antiretroviral therapy (HAART). Autoimmune and inflammatory diseases are rarely associated with this condition.
View Article and Find Full Text PDFMed Trop Sante Int
December 2024
Centre médico-social, Ville de Paris, 3 rue de Ridder, 75014, Paris, France.
The authors report on activities carried out in the 1990s in Côte d'Ivoire using original AIDS prevention methods. These initiatives were based on the use of loincloths. The loincloth is a printed fabric that is highly valued in Africa.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!