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| http://dx.doi.org/10.1016/j.omtn.2025.102484 | DOI Listing |
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Electrochemical N-Formylation of Amines: Mechanistic Insights and Sustainable Synthesis of Formamides via a Methylisocyanide Intermediate.
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Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands.
Electrochemical methodologies offer a transformative approach to sustainable chemical synthesis by enabling precise, energy-efficient transformations. Here, we report the selective electrochemical N-formylation of methylamine using methanol as both reagent and solvent, facilitated by a simple glassy carbon electrode. Under optimized conditions, we achieve a faradaic efficiency (FE) of 34% for methylformamide synthesis in a neutral NaClO electrolyte.
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Centre for Neurology, Department of Neurodegenerative Diseases, and Hertie Institute for Clinical Brain Research, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.
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Co-crystal engineering is of interest for many applications in pharmaceutical, chemistry and material fields, but rational design of co-crystals is still challenging. Although artificial intelligence has brought major changes in the decision-making process for materials design, yet limitations in generalization and mechanistic understanding remain. Herein, we sought to improve prediction of co-crystal by combining mechanistic thermodynamic modeling with machine learning.
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