Extracorporeal membrane oxygenation (ECMO) has emerged as a vital circulatory life support measure for patients with critical cardiac or pulmonary conditions unresponsive to conventional therapies. ECMO allows blood to be extracted from a patient and introduced to a machine that oxygenates blood and removes carbon dioxide. This blood is then reintroduced into the patient's circulatory system. This process makes ECMO essential for treating various medical conditions, both as a standalone therapy and as adjuvant therapy. Veno-venous (VV) ECMO primarily supports respiratory function and indicates respiratory distress. Simultaneously, veno-arterial (VA) ECMO provides hemodynamic and respiratory support and is suitable for cardiac-related complications. This study reviews recent literature to elucidate the evolving role of ECMO in trauma care, considering its procedural intricacies, indications, contraindications, and associated complications. Notably, the use of ECMO in trauma patients, particularly for acute respiratory distress syndrome and cardiogenic shock, has demonstrated promising outcomes despite challenges such as anticoagulation management and complications such as acute kidney injury, bleeding, thrombosis, and hemolysis. Some studies have shown that VV ECMO was associated with significantly higher survival rates than conventional mechanical ventilation, whereas other studies have reported that VA ECMO was associated with lower survival rates than VV ECMO. ECMO plays a critical role in managing trauma patients, particularly those with acute respiratory failure. Further research is necessary to explore the full potential of ECMO in trauma care. Clinicians should have a clear understanding of the indications and contraindications for the use of ECMO to maximize its benefits in treating trauma patients.
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http://dx.doi.org/10.5492/wjccm.v14.i1.96694 | DOI Listing |
Int J Surg
March 2025
Department of Digestive and Emergency Surgery, "S.Maria" Hospital, Terni, Italy.
Background: The management of high-surgical risk patients with moderate to severe acute cholecystitis is challenging in clinical practice. Early laparoscopic cholecystectomy is considered the gold standard for patients who do not respond to conservative treatment. However, for those unfit for surgery due to high-surgical risk, alternative treatment options such as percutaneous cholecystostomy (PC) are available.
View Article and Find Full Text PDFJ Pediatr Orthop B
March 2025
Department of Orthopaedics, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Deemed to be University Pimpri, Pune, Maharashtra, India.
Supracondylar humerus fractures comprise of a major part in pediatric trauma cases. They result from a fall on an outstretched hand. The rotational components of Gartland type III fractures if not corrected appropriately can lead to cubitus varus (gun stock deformity).
View Article and Find Full Text PDFCells
February 2025
Renal Division, Department of Medicine, Peking University First Hospital, Beijing 100034, China.
Diabetic nephropathy (DN), one of the most common complications of diabetes mellitus (DM), accounts for a major cause of chronic kidney disease (CKD) worldwide, with a complicated pathogenesis and limited effective strategies nowadays. The mineralocorticoid receptor (MR) is a classical ligand-activated nuclear transcription factor. It is expressed in the renal intrinsic and immune cells, especially macrophages.
View Article and Find Full Text PDFCells
February 2025
Institute of Molecular Medicine, National Tsing Hua University, No. 101, Section 2, Kuang-Fu Road, Hsinchu 300044, Taiwan.
Brain injuries can result from accidents, warfare, sports injuries, or brain diseases. Identifying regeneration-associated genes (RAGs) during epigenome remodeling upon brain injury could have a significant impact on reducing neuronal death and subsequent neurodegeneration for patients with brain injury. We previously identified several WNT genes as RAGs involved in the neurite regrowth of injured cortical neurons.
View Article and Find Full Text PDFCurr Opin Anaesthesiol
February 2025
Northwestern University, Feinberg School of Medicine.
Purpose Of Review: Traumatic childbirth can lead to childbirth-related post-traumatic stress disorder (CB-PTSD) or retraumatize those with prior trauma, contributing to long-term maternal and neonatal morbidity and mortality. This condition affects approximately 4-7% of postpartum patients. Given the concerningly high maternal morbidity and mortality rates in the USA, it is crucial to further analyze the risk factors and clinical management recommendations for the prevention of CB-PTSD.
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