Unlabelled: Optoretinography is an emerging method for detecting and measuring functional responses from neurons in the living human retina. Its potential applications are significant and broad, spanning clinical assessment of retinal disease, investigation of fundamental scientific questions, and rapid evaluation of experimental therapeutics for blinding retinal diseases. Progress in all these domains hinges on the development of robust methods for quantifying observed responses in relation to visible stimuli. In this work, we describe a novel optoretinographic imaging platform-full-field swept-source optical coherence tomography with adaptive optics, measure cone responses in two healthy volunteers to a variety of stimulus patterns, and propose a simple model for predicting and quantifying responses to those stimuli.
Teaser: The function of human retinal neurons is quantified by the light they reflect, opening a new frontier in visual health.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11888417 | PMC |
| http://dx.doi.org/10.1101/2025.02.28.639986 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Frequent disturbance to a foundation species disrupts consumer-mediated nutrient cycling in giant kelp forests.
Ecology
March 2025
Marine Science Institute, University of California, Santa Barbara, California, USA.
Structure-forming foundation species facilitate consumers by providing habitat and refugia. In return, consumers can benefit foundation species by reducing top-down pressures and increasing the supply of nutrients. Consumer-mediated nutrient dynamics (CND) fuel the growth of autotrophic foundation species and generate more habitat for consumers, forming reciprocal feedbacks.
View Article and Find Full Text PDFxDev: a mixed-signal, software-defined neurotechnology interface platform for accelerated system development.
J Neural Eng
March 2025
Center for Neurorestoration and Neurotechnology, Providence VA Medical Center, Providence, RI, United States of America.
Advances in electronics and materials science have led to the development of sophisticated components for clinical and research neurotechnology systems. However, instrumentation to easily evaluate how these components function in a complete system does not yet exist. In this work, we set out to design and validate a software-defined mixed-signal routing fabric, 'xDev', that enables neurotechnology system designers to rapidly iterate, evaluate, and deploy advanced multi-component systems.
View Article and Find Full Text PDFFactors influencing vaccine hesitancy among United Kingdom adolescents in a senior high school environment and actions to address it.
Hum Vaccin Immunother
December 2025
Sixth Form Department, Townley Grammar School, Bexleyheath, UK.
We explored adolescent viewpoints on vaccines and hesitancy using an anonymized, validated, self-completed electronic questionnaire amongst state-school Year 12-13 adolescents in London, UK. As the response rate was low (Cohort 1; = 112/486, 23.0%), we repeated the survey with incoming students (cohort 2, = 256/275; 93%).
View Article and Find Full Text PDFRobust Sensory Traits Across Light Habitats: Visual Signals but Not Receptors Vary in Centrarchids Inhabiting Distinct Photic Environments.
Mol Ecol
March 2025
Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.
Visual communication in fish is often shaped by their light environment, which influences both sensory (e.g., eye size, opsin gene expression) and signalling traits (e.
View Article and Find Full Text PDFFacile integration of single-crystalline phthalocyanine nanowires and nanotrees as photo-enhanced conductometric sensors.
Nanoscale
March 2025
Nanotechnology on Surfaces and Plasma Lab, Materials Science Institute of Seville (CSIC-US), Americo Vespucio 49, 41092 Seville, Spain.
This article presents a reproducible and affordable methodology for fabricating organic nanowires (ONWs) and nanotrees (ONTs) as light-enhanced conductometric O sensors. This protocol is based on a solventless procedure for the formation of high-density arrays of nanowires and nanotrees on interdigitated electrodes. The synthesis combines physical vapour deposition for the self-assembled growth of free-phthalocyanine nanowires and soft plasma etching to prompt the nucleation sites on the as-grown ONWs to allow for the formation of nanotrees.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!