Sexual and gender minority (SGM) individuals who are assigned-female-at-birth (i.e., sexual minority women, transgender men, and gender diverse individuals [SMWTGD]) experience an increased risk for negative mental health outcomes due to minority stress related to their minoritized identity. One proposed protective factor against negative mental health outcomes is resilience, which is one's ability to effectively achieve positive outcomes following stressful events. Past research shows cross-sectional associations between resilience and mental health in both the general population and SGM individuals. However, we know of no longitudinal research testing whether resilience prospectively predicts mental health, or whether the prospective associations between resilience and mental health differ by demographics. Self-reports of resilience, depression, anxiety, suicidality, and substance use were collected at two time-points 6 months apart from 453 SMWTGD late adolescents and young adults who reside in the Midwest region of the United States. Time 1 resilience was negatively associated with Time 2 depression, anxiety, and suicidal ideation, but not problematic substance use, controlling for Time 1 mental health. These associations were not moderated by demographic factors, suggesting that resilience operates consistently across most racial, sexual orientation, and gender identities within the SMWTGD community. These findings underscore the potential value of tailored interventions aimed at promoting resilience within SMWTGD.
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http://dx.doi.org/10.1080/19419899.2024.2369793 | DOI Listing |
JAMA Psychiatry
March 2025
Center for Neuropsychiatric Schizophrenia Research (CNSR& Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.
Importance: Maternal inflammation during pregnancy has been associated with an increased risk of neurodevelopmental disorders (NDDs), such as attention-deficit/hyperactivity disorder (ADHD) and autism, and cognitive deficits in early childhood. However, little is known about the contributions of a wider range of inflammatory proteins to this risk.
Objective: To determine whether maternal inflammatory proteins during pregnancy are associated with the risk of NDDs and executive functions (EF) in middle childhood and to identify protein patterns associated with NDDs and EF.
JAMA Psychiatry
March 2025
Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Importance: Expectancy effects are significant confounding factors in psychiatric randomized clinical trials (RCTs), potentially affecting the interpretation of study results. This narrative review is the first, to our knowledge, to explore the relationship between expectancy effects, compromised blinding integrity, and the effects of active treatment/placebo in psychiatric RCTs. Additionally, we present statistical and experimental approaches that may help mitigate the confounding impact of expectancy effects.
View Article and Find Full Text PDFJAMA Netw Open
March 2025
Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Australas Psychiatry
March 2025
Headspace Darwin, Darwin, NT, Australia.
JAMA Psychiatry
March 2025
Phoenix Australia-Centre for Posttraumatic Mental Health, Department of Psychiatry, University of Melbourne, Carlton, Victoria, Australia.
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