Editorial: Allergy in the Asia Pacific.

Front Allergy

Division of Rheumatology and Clinical Immunology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.

Published: February 2025

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885486PMC
http://dx.doi.org/10.3389/falgy.2025.1567647DOI Listing

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Article Synopsis
  • In April 2024, the European Summit on chronic respiratory diseases (CRDs) was held in the European Parliament, organized by EUFOREA and hosted by MEPs Dorien Rookmaker and Mislav Kolakušić.
  • The Summit aimed to address the challenges faced by European patients with CRDs by fostering collaboration among various European and global health organizations.
  • Representatives from multiple societies and patient associations discussed strategies to improve respiratory care and prevention by sharing their visions and action plans.
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Introduction: The pathogenesis of cold urticaria (ColdU) and cold-induced anaphylaxis (ColdA) remains poorly understood, and ColdA is underrepresented in anaphylaxis literature. Laboratory features to guide management are largely unknown. This study evaluated basal serum tryptase (BST) and total immunoglobulin E (IgE) levels in ColdU and ColdA, their associations with clinical features, and the utility of testing for the p.

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Two rare mutations in homozygosity synergize to silence TREX1 in Aicardi-Goutières syndrome.

Front Immunol

March 2025

IMMUNO-GRAM (Infection and IMMunity Genetic Research to Advance Molecular Medicine) Center of Reference, Research Institute - McGill University Health Centre, Montreal, QC, Canada.

Background: Aicardi-Goutières syndrome (AGS) is a rare monogenic type I interferonopathy characterized by dysregulated inflammation and tissue damage that primarily affects the central nervous system. AGS is genetically diverse, with pathogenic variants across multiple genes, including TREX1, which drives excessive type I interferon (IFN) production.

Objective: This study investigated the genetic and molecular mechanisms underlying AGS in a family of two affected children, focusing on the role of variants in protein expression and dysregulation of the interferon pathway.

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Editorial: Allergy in the Asia Pacific.

Front Allergy

February 2025

Division of Rheumatology and Clinical Immunology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.

View Article and Find Full Text PDF

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